Recovery of the pubic symphysis on primiparous young and multiparous senescent mice at postpartum

dc.creatorConsonni, SR
dc.creatorRosa, RG
dc.creatorNascimento, MAC
dc.creatorVinagre, CM
dc.creatorToledo, OMS
dc.creatorJoazeiro, PP
dc.date2012
dc.dateJUL
dc.date2014-08-01T18:33:29Z
dc.date2015-11-26T17:05:24Z
dc.date2014-08-01T18:33:29Z
dc.date2015-11-26T17:05:24Z
dc.date.accessioned2018-03-28T23:53:46Z
dc.date.available2018-03-28T23:53:46Z
dc.identifierHistology And Histopathology. F Hernandez, v. 27, n. 7, n. 885, n. 896, 2012.
dc.identifier0213-3911
dc.identifierWOS:000304592900007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80745
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80745
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279575
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIt has been observed that parturition has a significant effect on female skeletal architecture and that age alters musculoskeletal tissues and their functions. We therefore hypothesized that multiparity affects the recovery of the pubic symphysis in senescent mice at postpartum and the morphology of the interpubic tissues. The pubic symphysis of primiparous young, virgin senescent (VS) and multiparous senescent (MS) Swiss mice was examined by light microscopy, transmission electron microscopy, morphometric analysis and immunohistochemistry. The mouse pubic symphysis was remodeled during the first pregnancy: the cellular phenotype and morphology changed to ensure a structurally safe birth canal, followed by recovery of the interpubic articulation after birth. The morphology of the pubic symphysis in the VS group was maintained in a state similar to that observed in virgin young mice. In contrast, MS mice exhibited an interpubic ligament characterized by extended fibrocyte-like cells, an opened interpubic articulation gap, compacted and thin collagen fibrils and scarce galectin-3-positive cells. Thus, we found that the cellular and extracellular characteristics of the pubic symphysis were altered by multiparity in senescent mice. These particular tissue characteristics of the MS group might be associated with an impaired recovery process at postpartum. Thus, a better understanding of the alterations that occur in the birth canal, including the pubic symphysis, due to multiparity in reproductively aged mice may contribute to our comprehension of the biological mechanisms that modify the skeleton and pelvic ligaments and even play a role in the murine model of pelvic organ prolapse.
dc.description27
dc.description7
dc.description885
dc.description896
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2007/50823-2]
dc.descriptionCNPq [308169/2009-3]
dc.languageen
dc.publisherF Hernandez
dc.publisherMurcia
dc.publisherEspanha
dc.relationHistology And Histopathology
dc.relationHistol. Histopath.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectPubic symphysis
dc.subjectGalectin-3
dc.subjectReproduction
dc.subjectMultiparity
dc.subjectSenescent mouse
dc.subjectPelvic Organ Prolapse
dc.subjectAge-related-changes
dc.subjectElastic Fiber Homeostasis
dc.subjectSexual-dimorphism
dc.subjectRheumatoid-arthritis
dc.subjectCollagen Fibrils
dc.subjectLate Pregnancy
dc.subjectKnockout Mice
dc.subjectIn-vivo
dc.subjectMouse
dc.titleRecovery of the pubic symphysis on primiparous young and multiparous senescent mice at postpartum
dc.typeArtículos de revistas


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