Solubility of cyclomaltooligosaccharides (cyclodextrins) in H2O and D2O: a comparative study

dc.creatorSabadini, E
dc.creatorCosgrove, T
dc.creatorEgidio, FC
dc.date2006
dc.dateFEB 6
dc.date2014-11-19T10:48:35Z
dc.date2015-11-26T17:05:19Z
dc.date2014-11-19T10:48:35Z
dc.date2015-11-26T17:05:19Z
dc.date.accessioned2018-03-28T23:53:40Z
dc.date.available2018-03-28T23:53:40Z
dc.identifierCarbohydrate Research. Elsevier Sci Ltd, v. 341, n. 2, n. 270, n. 274, 2006.
dc.identifier0008-6215
dc.identifierWOS:000234869700011
dc.identifier10.1016/j.carres.2005.11.004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71831
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71831
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71831
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279555
dc.descriptionCyclomaltooligosaccharides (cyclodextrins, CDs) are cyclic oligomers having six, seven, or eight units of alpha-D-glucose, named as cyclomaltohexaose (alpha-CD), cyclomaltoheptaose (beta-CD) and cyclomaltooctaose (gamma-CD), respectively. The molecule of CD has a cavity in which the interior is hydrophobic relative to its outer surface. The solubility of cyclodextrins in water is unusual, as an irregular trend is observed in the series of the cyclic oligomers of glucose. beta-CD is at least nine times less soluble than the others CDs. This intriguing behavior has been investigated, and some interesting explanations in terms of the effect caused by CD on the water lattice structure have been proposed. In this work a comparative study on the solubility of alpha, beta, and gamma-cyclodextrins was carried out in H2O and D2O and reveals a much lower solubility of the three CDs in D2O. The solid-phase structure of the CDs in equilibrium with the solution is quite similar with both solvents. The results are discussed in terms of the CD molecular structure and the differences in the hydrogen bonds formed between H2O and D2O. (c) 2005 Elsevier Ltd. All rights reserved.
dc.description341
dc.description2
dc.description270
dc.description274
dc.languageen
dc.publisherElsevier Sci Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationCarbohydrate Research
dc.relationCarbohydr. Res.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectsolubility of cyclodextrins in H2O and D2O
dc.subjecthydrogen bonding
dc.subjecthydrophobic effect
dc.subjectBeta-cyclodextrin
dc.subjectAlpha-cyclodextrin
dc.subjectWater
dc.subjectSolvent
dc.subjectTemperature
dc.subjectComplexes
dc.titleSolubility of cyclomaltooligosaccharides (cyclodextrins) in H2O and D2O: a comparative study
dc.typeArtículos de revistas


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