Solid-phase fluorescence spectroscopy for the determination of acetylsalicylic acid in powdered pharmaceutical samples

dc.creatorMoreira, AB
dc.creatorDias, ILT
dc.creatorNeto, GO
dc.creatorZagatto, EAG
dc.creatorKubota, LT
dc.date2004
dc.dateOCT 4
dc.date2014-11-19T10:28:16Z
dc.date2015-11-26T17:05:04Z
dc.date2014-11-19T10:28:16Z
dc.date2015-11-26T17:05:04Z
dc.date.accessioned2018-03-28T23:53:25Z
dc.date.available2018-03-28T23:53:25Z
dc.identifierAnalytica Chimica Acta. Elsevier Science Bv, v. 523, n. 1, n. 49, n. 52, 2004.
dc.identifier0003-2670
dc.identifierWOS:000224039700008
dc.identifier10.1016/j.aca.2004.06.011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71809
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71809
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71809
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279492
dc.descriptionA rapid, simple and rugged procedure without requiring any prior sample treatment was developed for the determination of acetylsalicylic acid (ASA) in tablets formulations by solid-phase fluorescence spectroscopy. The method was carried out on powdered samples, consisting of an active substance dispersed in lactose, maize starch, talc and magnesium stearate. Previous knowledge of the sample bulk composition is needed for proper application of the method. Wavelengths for maximum excitation and emission were 288 and 318 nm, respectively, and the fluorescence intensity was linear with ASA concentration within the 50-170 mg g(-1) range. Detection and quantification limits were 2.2 and 7.3 mg g(-1), and the analytical frequency was 200 h(-1). For a typical sample, the relative standard deviation of results was estimated as 2.3% (n = 10). Accuracy was assessed by comparing the analytical results obtained with the proposed method with those related to a reference method recommended by British Pharmacopoeia: no differences between the methods were found at the 95% confidence level. (C) 2004 Elsevier B.V. All rights reserved.
dc.description523
dc.description1
dc.description49
dc.description52
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationAnalytica Chimica Acta
dc.relationAnal. Chim. Acta
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectsolid-phase analysis
dc.subjectfluorescence spectroscopy
dc.subjectacetylsalicylic acid
dc.subjectnon-destructive analysis
dc.subjectSpectrofluorometric Determination
dc.subjectMultivariate Calibration
dc.subjectTablet Formulations
dc.subjectInjection-analysis
dc.subjectSalicylic-acid
dc.subjectAscorbic-acid
dc.subjectCaffeine
dc.subjectParacetamol
dc.subjectMixtures
dc.subjectCodeine
dc.titleSolid-phase fluorescence spectroscopy for the determination of acetylsalicylic acid in powdered pharmaceutical samples
dc.typeArtículos de revistas


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