Th1/Th2 cytokine profile in childhood-onset systemic lupus erythematosus

dc.creatorPostal, M
dc.creatorPelicari, KO
dc.creatorSinicato, NA
dc.creatorMarini, R
dc.creatorCostallat, LTL
dc.creatorAppenzeller, S
dc.date2013
dc.dateMAR
dc.date2014-08-01T18:25:09Z
dc.date2015-11-26T17:04:16Z
dc.date2014-08-01T18:25:09Z
dc.date2015-11-26T17:04:16Z
dc.date.accessioned2018-03-28T23:52:31Z
dc.date.available2018-03-28T23:52:31Z
dc.identifierCytokine. Academic Press Ltd- Elsevier Science Ltd, v. 61, n. 3, n. 785, n. 791, 2013.
dc.identifier1043-4666
dc.identifier1096-0023
dc.identifierWOS:000316577900018
dc.identifier10.1016/j.cyto.2012.11.023
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78663
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78663
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279299
dc.descriptionObjective: To determine the serum levels of Th1 (IL-12, IFN-gamma,TNF-alpha) and Th2 (IL-5, IL-6 and IL-10) cytokines in childhood-onset SLE, first-degree relatives and healthy controls. To elucidate their association with disease activity, laboratory and treatment features. Methods: We included 60 consecutive childhood-onset SLE patients [median age 18 years (range 10-37)], 64 first-degree relatives [median 40 (range 28-52)] and 57 healthy [median age 19 years (range 630 years)] controls. Controls were age and sex-matched to SLE patients. SLE patients were assessed for clinical and laboratory SLE manifestations, disease activity (SLEDAI), damage (SDI) and current drug exposures. Mood and anxiety disorders were determined through Becks Depression (BDI) and Anxiety Inventory (BAI). Th1 (IL-12, IFN-gamma,TNF-alpha) and Th2 (IL-5, IL-6 and IL-10) cytokines levels were measured by ELISA and compared by non-parametric tests. Results: Serum TNF-alpha (p = 0.004), IL-6 (p = 0.007) and IL-10 (p = 0.03) levels were increased in childhood-onset SLE patients when compared to first-degree relatives and healthy controls. TNF-alpha levels were significantly increased in patients with active disease (p = 0.014) and correlated directly with SLEDAI scores (r = 0.39; p = 0.002). IL-12 (p = 0.042) and TNF-alpha (p = 0.009) levels were significantly increased in patients with nephritis and TNF-alpha in patients with depression (p = 0.001). No association between cytokine levels and SDI scores or medication was observed. Conclusion: Th1 cytokines may play a role in the pathogenesis of neuropsychiatric and renal manifestations in childhood-onset SLE. The correlation with SLEDAI suggests that TNF-alpha may be a useful biomarker for disease activity in childhood-onset SLE, however longitudinal studies are necessary to determine if increase of this cytokine may predict flares in childhood-onset SLE. (C) 2012 Elsevier Ltd. All rights reserved.
dc.description61
dc.description3
dc.description785
dc.description791
dc.languageen
dc.publisherAcademic Press Ltd- Elsevier Science Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationCytokine
dc.relationCytokine
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectInterferon gamma (IFNI-gamma)
dc.subjectTumor necrosis factor alpha (TNF-alpha)
dc.subjectInterleukin (IL) 5, 6, 10, and 12
dc.subjectSLEDAI
dc.subjectChildhood-onset systemic lupus erythematosus
dc.subjectTumor-necrosis-factor
dc.subjectMajor-depressive-disorder
dc.subjectPro-inflammatory Cytokines
dc.subjectRegulatory T-cells
dc.subjectDisease-activity
dc.subjectFactor-alpha
dc.subjectAdult-onset
dc.subjectTnf-alpha
dc.subjectEgyptian Patients
dc.subjectProinflammatory Cytokines
dc.titleTh1/Th2 cytokine profile in childhood-onset systemic lupus erythematosus
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución