Ehrlich ascites tumor as a tool in the development of compounds with immunomodulatory properties

dc.creatorQueiroz, MLS
dc.creatorValadares, MC
dc.creatorBincoletto, C
dc.creatorDieamant, GC
dc.date2004
dc.date2014-11-19T08:11:11Z
dc.date2015-11-26T17:04:08Z
dc.date2014-11-19T08:11:11Z
dc.date2015-11-26T17:04:08Z
dc.date.accessioned2018-03-28T23:52:22Z
dc.date.available2018-03-28T23:52:22Z
dc.identifierImmunopharmacology And Immunotoxicology. Marcel Dekker Inc, v. 26, n. 4, n. 511, n. 525, 2004.
dc.identifier0892-3973
dc.identifierWOS:000226220000003
dc.identifier10.1081/IPH-200042289
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65385
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/65385
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65385
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279275
dc.descriptionIn previous works, we have demonstrated that the myeloprotective properties of several natural and synthetic compounds are partly responsible for their antitumor activity in the Ehrlich ascites tumor (EAT) model. In this work, we present information that may be useful to the study of pharmacological and toxicological properties of compounds that affect the hematological compartment. Clonogenic studies in EAT-inoculated mice demonstrated a rapid decrease in bone marrow CFU-GM, whereas a progressive increase in splenic CFU-GM and cellularity was observed, followed by splenomegaly. Bone marrow cellularity declined on the third day after tumor challenge, returning to normal values thereafter. Serum from EAT-bearing mice produced detectable colony-stimulating activity in vitro. Similar results were observed with the conditioned medium from Ehrlich tumor cell cultures, but not with the cell-free Ehrlich tumor ascitic fluid. Tumor inoculation also resulted in a more striking depletion in the number of non-adherent cells in long-term bone marrow cell cultures (LTBMCs) with no bone marrow stroma formation. We speculate that the physiological alterations induced by the EAT growth can be used to assess the ability of compounds to modulate the hematopoietic response.
dc.description26
dc.description4
dc.description511
dc.description525
dc.languageen
dc.publisherMarcel Dekker Inc
dc.publisherNew York
dc.publisherEUA
dc.relationImmunopharmacology And Immunotoxicology
dc.relationImmunopharmacol. Immunotoxicol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectEhrlich ascites tumor
dc.subjectdevelopment of antitumoral compounds
dc.subjectimmunomodulation
dc.subjecthematopoiesis
dc.subjectCFU-GM
dc.subjectlong-term bone marrow culture
dc.subjectHematopoietic Stem-cells
dc.subjectColony-stimulating Factors
dc.subjectBone-marrow Cultures
dc.subjectLong-term Cultures
dc.subjectBearing Mice
dc.subjectStromal Cells
dc.subjectCfu-c
dc.subjectProliferation
dc.subjectGrowth
dc.subjectDifferentiation
dc.titleEhrlich ascites tumor as a tool in the development of compounds with immunomodulatory properties
dc.typeArtículos de revistas


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