TsTX-VII, a new toxin from Tityus serrulatus scorpion venom able to induce the release of neurotransmitters from rat brain synaptosomes not blocked by tetrodotoxin

dc.creatorSampaio, SV
dc.creatorCoutinhoNetto, J
dc.creatorArantes, EC
dc.creatorToyama, MH
dc.creatorNovello, JC
dc.creatorGiglio, JR
dc.date1997
dc.dateMAY
dc.date2014-08-01T18:19:03Z
dc.date2015-11-26T17:04:02Z
dc.date2014-08-01T18:19:03Z
dc.date2015-11-26T17:04:02Z
dc.date.accessioned2018-03-28T23:52:14Z
dc.date.available2018-03-28T23:52:14Z
dc.identifierBiochemistry And Molecular Biology International. Academic Press Aust, v. 41, n. 6, n. 1255, n. 1263, 1997.
dc.identifier1039-9712
dc.identifierWOS:A1997WZ27600021
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77051
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77051
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279246
dc.descriptionA procedure for the isolation of the toxin Tityustoxin VII (TsTX-VII) from Tityus serrulatus scorpion venom and its biochemical characterization is reported. This protein has a Mr = 6,700 - 6,800, eight half-cystine residues accounting for four disulfide bridges and no His. Its N-terminal sequence GHZGYGS ....... characterizes it as a new toxin, able to release glutamic acid and gamma aminobutyric acid from rat brain synaptosomes 'in vitro'. This release was also induced by the whole venom. Tetrodotoxin however blocked the effect of the whole venom but not that of TsTX-VII, thus suggesting that the releasing mechanism by TsTX-VII does not involve Na+ but perhaps K+ or Ca++ channels.
dc.description41
dc.description6
dc.description1255
dc.description1263
dc.languageen
dc.publisherAcademic Press Aust
dc.publisherMarrickville
dc.publisherAustralia
dc.relationBiochemistry And Molecular Biology International
dc.relationBiochem. Mol. Biol. Int.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjecttityustoxin-VII
dc.subjectTityus serrulatus
dc.subjectscorpion venom
dc.subjectneurotransmitters
dc.subjectsynaptosomes
dc.subjecttetrodotoxin
dc.subjectGamma-toxin
dc.subjectNa+ Channel
dc.subjectPotassium Channels
dc.subjectHigh-affinity
dc.subjectInactivation
dc.subjectNeurotoxin
dc.subjectMembrane
dc.subjectPeptide
dc.titleTsTX-VII, a new toxin from Tityus serrulatus scorpion venom able to induce the release of neurotransmitters from rat brain synaptosomes not blocked by tetrodotoxin
dc.typeArtículos de revistas


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