Infratentorial gray matter atrophy and excess in primary craniocervical dystonia

dc.creatorPiccinin, CC
dc.creatorSantos, MCA
dc.creatorPiovesana, LG
dc.creatorCampos, LS
dc.creatorGuimaraes, RP
dc.creatorCampos, BM
dc.creatorTorres, FR
dc.creatorFranca, MC
dc.creatorAmato, AC
dc.creatorLopes-Cendes, I
dc.creatorCendes, F
dc.creatorD'Abreu, A
dc.date2014
dc.dateFEB
dc.date2014-08-01T18:32:50Z
dc.date2015-11-26T17:03:27Z
dc.date2014-08-01T18:32:50Z
dc.date2015-11-26T17:03:27Z
dc.date.accessioned2018-03-28T23:51:35Z
dc.date.available2018-03-28T23:51:35Z
dc.identifierParkinsonism & Related Disorders. Elsevier Sci Ltd, v. 20, n. 2, n. 198, n. 203, 2014.
dc.identifier1353-8020
dc.identifier1873-5126
dc.identifierWOS:000331685500013
dc.identifier10.1016/j.parkreldis.2013.10.026
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80551
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80551
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279076
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: Primary craniocervical dystonia (CCD) is generally attributed to functional abnormalities in the cortico striato pallido thalamocortical loops, but cerebellar pathways have also been implicated in neuroimaging studies. Hence, our purpose was to perform a volumetric evaluation of the infratentorial structures in CCD. Methods: We compared 35 DYT1/DYT6 negative patients with CCD and 35 healthy controls. Cerebellar volume was evaluated using manual volumetry (DISPLAY software) and infratentorial volume by voxel based morphometry of gray matter (GM) segments derived from T1 weighted 3 T MRI using the SUIT tool (SPM8/Dartel). We used t-tests to compare infratentorial volumes between groups. Results: Cerebellar volume was (1.14 +/- 0.17) x 10(2) cm(3) for controls and (1.13 +/- 0.14) x 10(2) cm(3) for patients; p = 0.74. VBM demonstrated GM increase in the left I IV cerebellar lobules and GM decrease in the left lobules VI and Crus I and in the right lobules VI, Crus I and VIIIb. In a secondary analysis, VBM demonstrated GM increase also in the brainstem, mostly in the pons. Conclusion: While gray matter increase is observed in the anterior lobe of the cerebellum and in the brainstem, the atrophy is concentrated in the posterior lobe of the cerebellum, demonstrating a differential pattern of infratentorial involvement in CCD. This study shows subtle structural abnormalities of the cerebellum and brainstem in primary CCD. (C) 2013 Elsevier Ltd. All rights reserved.
dc.description20
dc.description2
dc.description198
dc.description203
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherElsevier Sci Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationParkinsonism & Related Disorders
dc.relationParkinsonism Relat. Disord.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectCraniocervical dystonia
dc.subjectInfratentorial
dc.subjectCerebellum
dc.subjectVoxel based morphometry
dc.subjectSUIT tool
dc.subjectVoxel Based Morphometry
dc.subjectCervical Dystonia
dc.subjectBrain
dc.subjectCerebellum
dc.subjectMovement
dc.subjectLesions
dc.subjectSystem
dc.titleInfratentorial gray matter atrophy and excess in primary craniocervical dystonia
dc.typeArtículos de revistas


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