Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs

dc.creatorde Lima, DP
dc.creatorRotta, R
dc.creatorBeatriz, A
dc.creatorMarques, MR
dc.creatorMontenegro, RC
dc.creatorVasconcellos, MC
dc.creatorPessoa, C
dc.creatorde Moraes, MO
dc.creatorCosta-Lotufo, LV
dc.creatorSawaya, ACHF
dc.creatorEberlin, MN
dc.date2009
dc.dateFEB
dc.date2014-11-19T05:35:02Z
dc.date2015-11-26T17:02:41Z
dc.date2014-11-19T05:35:02Z
dc.date2015-11-26T17:02:41Z
dc.date.accessioned2018-03-28T23:50:47Z
dc.date.available2018-03-28T23:50:47Z
dc.identifierEuropean Journal Of Medicinal Chemistry. Elsevier France-editions Scientifiques Medicales Elsevier, v. 44, n. 2, n. 701, n. 707, 2009.
dc.identifier0223-5234
dc.identifierWOS:000264407800027
dc.identifier10.1016/j.ejmech.2008.05.003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74021
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/74021
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74021
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278935
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThis work deals with the preparation of stilbene-based resveratrol analogs by employing the Perkin reaction, aiming at synthesizing potential antitumor lead compounds and evaluating their pharmacological activities. The proliferation inhibitor test against tumor cell lines identified analogs 9 and 11 as the most active among all synthesized derivatives, presenting IC(50) in micromolar range for certain cell lines. For study on the embryonic development, compounds 8 and 9 at the lowest tested concentration (41.7 mu M) that inhibited sea urchin egg development, but only after third cleavage were used. Both the compounds inhibited 100% of normal development since first cleavage. These data partially corroborated the results obtained with MTT assay using tumor cell lines. None of the tested compounds revealed hemolytic action in assay with mouse erythrocytes. (c) 2008 Elsevier Masson SAS. All rights reserved.
dc.description44
dc.description2
dc.description701
dc.description707
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionKardol Ind. Qufmica Ltda.
dc.descriptionInstituto Claude Bernard
dc.descriptionFUNCAP
dc.descriptionBanco do Nordeste
dc.descriptionFINEP
dc.descriptionPROPP-UFMS
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.publisherParis
dc.publisherFrança
dc.relationEuropean Journal Of Medicinal Chemistry
dc.relationEur. J. Med. Chem.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectStilbenes
dc.subjectResveratrol analogs
dc.subjectCytotoxic properties
dc.subjectEmbryonic development
dc.subjectMethoxy-substituted Stilbenes
dc.subjectAsymmetric Hydrogenation
dc.subjectLithospermum-ruderale
dc.subjectPolyphenolic Acids
dc.subjectLeukemia-cells
dc.subjectIn-vitro
dc.subjectDerivatives
dc.subjectApoptosis
dc.subjectToxicity
dc.subjectExtracts
dc.titleSynthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs
dc.typeArtículos de revistas


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