A comparative study on the effect of nicotine administration and cigarette smoke inhalation on bone healing around titanium implants

dc.creatorCesar-Neto, JB
dc.creatorDuarte, PM
dc.creatorSallum, EA
dc.creatorBarbieri, D
dc.creatorMoreno, H
dc.creatorNociti, FH
dc.date2003
dc.dateOCT
dc.date2014-11-19T03:26:45Z
dc.date2015-11-26T17:01:22Z
dc.date2014-11-19T03:26:45Z
dc.date2015-11-26T17:01:22Z
dc.date.accessioned2018-03-28T23:49:12Z
dc.date.available2018-03-28T23:49:12Z
dc.identifierJournal Of Periodontology. Amer Acad Periodontology, v. 74, n. 10, n. 1454, n. 1459, 2003.
dc.identifier0022-3492
dc.identifierWOS:000187315900006
dc.identifier10.1902/jop.2003.74.10.1454
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/52966
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/52966
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/52966
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278703
dc.descriptionBackground: A series of isolated studies has focused on the influence of smoking on bone around titanium implants. This study proposes to investigate the impact of two conditions, i.e., nicotine administration and cigarette smoke inhalation, on the healing around implants. Methods: Forty-five Wistar rats were used. After anesthesia, the tibiae surface was exposed and a screw-shaped titanium implant was placed bilaterally. The animals were randomly assigned to one of the following groups: Group 1: control, n = 19; Group 2: intermittent cigarette smoke inhalation, n = 15; and Group 3: subcutaneous administration of nicotine (3 mg/kg) twice daily, n = 11. After 60 days, the animals were sacrificed. The degree of boneto-implant contact (BIC) and the bone area (BA) within the limits of the threads of the implant were measured in the cortical (zone A) and cancellous bone (zone B) areas. Results: In zone A, cigarette smoke presented a significant negative influence on BIC and BA (Kruskal-Wallis test, P<0.05). In contrast, the administration of nicotine did not influence either parameter (P>0.05). In zone B, cigarette smoke inhalation also resulted in a decreased percentage of BIC compared to the control group (P<0.05). In addition, the BA was significantly decreased in groups 2 and 3 when compared to controls (P>0.05). Conclusion: The negative impact of smoking on implant outcomes may be related to more than one molecule present in the cigarette smoke and nicotine seems to partially contribute, especially in the cancellous bone.
dc.description74
dc.description10
dc.description1454
dc.description1459
dc.languageen
dc.publisherAmer Acad Periodontology
dc.publisherChicago
dc.publisherEUA
dc.relationJournal Of Periodontology
dc.relationJ. Periodont.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectdental implants
dc.subjectnicotine/adverse effects
dc.subjectosseointegration
dc.subjectsmoking/adverse effects
dc.subjecttobacco/adverse effects
dc.subjectGingival Fibroblast Cytoskeleton
dc.subjectHydroxyapatite-coated Implants
dc.subjectOsteoblast-like Cells
dc.subjectIn-vitro
dc.subjectRats
dc.subjectAttachment
dc.subjectCotinine
dc.subjectRabbits
dc.subjectExpression
dc.subjectComponents
dc.titleA comparative study on the effect of nicotine administration and cigarette smoke inhalation on bone healing around titanium implants
dc.typeArtículos de revistas


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