Soy protein containing isoflavones favorably influences macrophage lipoprotein metabolism but not the development of atherosclerosis in CETP transgenic mice

dc.creatorAsakura, L
dc.creatorCazita, PM
dc.creatorHarada, LM
dc.creatorNunes, VS
dc.creatorBerti, JA
dc.creatorSalerno, AG
dc.creatorKetelhuth, DFJ
dc.creatorGidlund, M
dc.creatorOliveira, HCF
dc.creatorQuintao, ECR
dc.date2006
dc.dateJUL
dc.date2014-11-19T03:14:29Z
dc.date2015-11-26T17:01:14Z
dc.date2014-11-19T03:14:29Z
dc.date2015-11-26T17:01:14Z
dc.date.accessioned2018-03-28T23:49:04Z
dc.date.available2018-03-28T23:49:04Z
dc.identifierLipids. Amer Oil Chemists Soc A O C S Press, v. 41, n. 7, n. 655, n. 662, 2006.
dc.identifier0024-4201
dc.identifierWOS:000241071300004
dc.identifier10.1007/s11745-006-5016-7
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71966
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71966
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71966
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278667
dc.descriptionThe possibility that soy protein containing isoflavones influences the development of experimental atherosclerosis has been investigated in ovariectomized mice heterozygous for the human CETP transgene and for the LDL-receptor null allele (LDLr+/- CETP+/-). After ovariectomy at 8 wk of age they were fed a fat/cholesterol-rich diet for 19 wk and divided into three experimental groups: dietary unmodified soy protein containing isoflavones (mg/g of diet), either at low-dose (Iso Low, 0.272, n = 25), or at high-dose (Iso High, 0.535, n = 28); and the atherogenic diet containing an isoflavone-depleted alcohol-washed soy protein as a control group (n = 28). Aortic root lipid-stained lesion area (mean mu m(2) X 10(3) +/- SD) did not differ among]so Low (12.3 +/- 9.9),]so High (7.4 +/- 6.4), and controls (10.7 +/- 12.8). Autoantibody titers against plasma oxidized LDL did not differ among the experimental groups. Using the control mice as the reference value (100%), in vitro mouse peritoneal macrophage uptake of labeled acetylated LDL-cholesterol was lower in the Iso High (68%) than in the Iso Low (85%) group. The in vitro percent removal by exogenous HDL of labeled unesterified cholesterol from macrophages previously enriched with human [4-C-14]-cholesteryl oleate acetylated LDL was enhanced in the Iso High group (50%). In spite of these in vitro potentially antiatherogenic actions, soy protein containing isoflavones did not modify the average size of lipid-stained area in the aortic root.
dc.description41
dc.description7
dc.description655
dc.description662
dc.languageen
dc.publisherAmer Oil Chemists Soc A O C S Press
dc.publisherChampaign
dc.publisherEUA
dc.relationLipids
dc.relationLipids
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectLow-density-lipoprotein
dc.subjectHormone Replacement Therapy
dc.subjectRandomized Controlled-trial
dc.subjectReceptor-deficient Mice
dc.subjectEster Transfer Protein
dc.subjectUp Hers-ii
dc.subjectPostmenopausal Women
dc.subjectCardiovascular-disease
dc.subjectOxidized Ldl
dc.subjectEstrogen/progestin Replacement
dc.titleSoy protein containing isoflavones favorably influences macrophage lipoprotein metabolism but not the development of atherosclerosis in CETP transgenic mice
dc.typeArtículos de revistas


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