Degradation of flumequine by the Fenton and photo-Fenton processes: Evaluation of residual antimicrobial activity

dc.creatorRodrigues-Silva, C
dc.creatorManiero, MG
dc.creatorRath, S
dc.creatorGuimaraes, JR
dc.date2013
dc.dateFEB 15
dc.date2014-08-01T18:28:05Z
dc.date2015-11-26T17:01:07Z
dc.date2014-08-01T18:28:05Z
dc.date2015-11-26T17:01:07Z
dc.date.accessioned2018-03-28T23:48:57Z
dc.date.available2018-03-28T23:48:57Z
dc.identifierScience Of The Total Environment. Elsevier Science Bv, v. 445, n. 337, n. 346, 2013.
dc.identifier0048-9697
dc.identifierWOS:000316826800036
dc.identifier10.1016/j.scitotenv.2012.12.079
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79392
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79392
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278641
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFlumequine is a broad-spectrum antimicrobial agent of the quinolone class, and it is widely used as a veterinary drug in food-producing animals. The presence of flumequine in the environment may contribute to the development of drug resistant bacterial strains. In this study, water samples fortified with flumequine (500 mu g L-1) were degraded using the Fenton and photo-Fenton processes. The maximum degradation efficiency for flumequine by the Fenton process was approximately 40% (05 mmol L-1 Fe(II), 2.0 mmol L-1 H2O2 and 15 min). By applying UV radiation (photo-Fenton process), the efficiency reached more than 94% in 60 min when 025 mmol L-1 Fe(II) and 10.0 mmol L-1 H2O2 were used. Under these conditions, the Fenton process was able to reduce the biological activity, whereas the photo-Fenton process eliminated almost all of the antimicrobial activity because it was not detected. Four byproducts with an m/z of 244, 238, 220 and 202 were identified by mass spectrometry, and a degradation pathway for flumequine was proposed. The byproducts were derived from decarboxylation and defluorination reactions and from modifications in the alkylamino chain of the fluoroquinolone. (C) 2013 Elsevier B.V. All rights reserved.
dc.description445
dc.description337
dc.description346
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCAPES [PNPD0233080]
dc.descriptionFAPESP [2008/06470-0]
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationScience Of The Total Environment
dc.relationSci. Total Environ.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAntimicrobial activity
dc.subjectByproducts
dc.subjectE. coli
dc.subjectFenton
dc.subjectFlumequine
dc.subjectPhoto-Fenton
dc.subjectAdvanced Oxidation Processes
dc.subjectAntibacterial Activity
dc.subjectOxolinic Acid
dc.subjectAntibiotics
dc.subjectToxicity
dc.subjectPharmacokinetics
dc.subjectFluoroquinolones
dc.subjectPhotochemistry
dc.subjectMarbofloxacin
dc.subjectProducts
dc.titleDegradation of flumequine by the Fenton and photo-Fenton processes: Evaluation of residual antimicrobial activity
dc.typeArtículos de revistas


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