Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians

dc.creatorRossit, ARB
dc.creatorCabral, IR
dc.creatorHackel, C
dc.creatorda Silva, RDMA
dc.creatorFroes, NDTC
dc.creatorAbdel-Rahman, SZ
dc.date2002
dc.date46905
dc.date2014-11-19T02:53:21Z
dc.date2015-11-26T17:01:04Z
dc.date2014-11-19T02:53:21Z
dc.date2015-11-26T17:01:04Z
dc.date.accessioned2018-03-28T23:48:52Z
dc.date.available2018-03-28T23:48:52Z
dc.identifierCancer Letters. Elsevier Sci Ireland Ltd, v. 180, n. 2, n. 173, n. 182, 2002.
dc.identifier0304-3835
dc.identifierWOS:000175963400009
dc.identifier10.1016/S0304-3835(02)00029-0
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70730
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70730
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70730
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278639
dc.descriptionThe population of Southeastern Brazil has a very high mortality rate from liver cirrhosis, a disease that is considered an irreversible pre-malignant condition. This is largely due to the high prevalence of alcohol abuse in the region, Chronic alcohol consumption is associated with the production of free radical intermediates that can cause several DNA lesions. Reduced repair of these DNA lesions would. therefore, constitute a significant risk factor for liver cirrhosis and subsequent cancer, Recently, a number of polymorphisms in several DNA repair genes have been discovered, and it is possible that these polymorphisms may affect DNA repair capacity and thus modulate susceptibility to the disease. In this study, we tested the hypothesis that polymorphisms in the DNA repair gene XRCC1 are associated with increased risk of liver cirrhosis in Southeastern Brazilians. We conducted a pilot case-control study of 97 liver cirrhosis cases and 96 controls (matched for age, sex, and ethnicity) to investigate the role of two allelic variants coding for amino acid changes in the XRCC1 gene (the Arg194Trp and the Arg399Gln polymorphisms). Overall, we observed a 1.8-fold increase in the relative risk of liver cirrhosis associated with the 399Gln allele (either the heterozygous ArglGln or the homozygous Gln/Gln genotypes). The adjusted odds ratio (OR) was 1.82 (95% confidence limit (CL) 1.10-3.30). The relative risk appears to be highest among the Mestiso ethnic group (OR 2.60. 95% CL 0.92-7.34). There was a significant association between the 399Gln polymorphism and the risk of liver cirrhosis in older individuals over the age of 45 years (OR 170 (95% CL 1.14-6.48) compared to an OR of 1,24 (95% CL 0.55-2.78) for those under 45 years of age. No association was observed between the XRCC1 194Trp polymorphism and risk of liver cirrhosis. These preliminary results suggest that the XRCCl 399Gln polymorphism may be a significant risk modifier for alcoholic liver cirrhosis and justifies additional studies in that direction. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
dc.description180
dc.description2
dc.description173
dc.description182
dc.languageen
dc.publisherElsevier Sci Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationCancer Letters
dc.relationCancer Lett.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectliver cirrhosis
dc.subjectDNA repair
dc.subjectgenetic polymorphism
dc.subjectXRCC1
dc.subjectbiomarkers
dc.subjectStrand Break Repair
dc.subjectOxidative Stress
dc.subjectHepatitis
dc.subjectDisease
dc.subjectDamage
dc.subjectRisk
dc.subjectCancer
dc.subjectInjury
dc.subjectCells
dc.subjectDehydrogenase
dc.titlePolymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians
dc.typeArtículos de revistas


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