Polymorphisms in the vitamin D receptor gene are associated with periodontal disease

dc.creatorde Brito, RB
dc.creatorScarel-Caminaga, RMS
dc.creatorTrevilatto, PC
dc.creatorde Souza, AP
dc.creatorBarros, SP
dc.date2004
dc.dateAUG
dc.date2014-11-19T02:47:48Z
dc.date2015-11-26T17:01:01Z
dc.date2014-11-19T02:47:48Z
dc.date2015-11-26T17:01:01Z
dc.date.accessioned2018-03-28T23:48:49Z
dc.date.available2018-03-28T23:48:49Z
dc.identifierJournal Of Periodontology. Amer Acad Periodontology, v. 75, n. 8, n. 1090, n. 1095, 2004.
dc.identifier0022-3492
dc.identifierWOS:000223509100008
dc.identifier10.1902/jop.2004.75.8.1090
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70732
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70732
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70732
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278626
dc.descriptionBackground: Genetic polymorphisms in the vitamin D receptor (VDR) gene are associated with bone homeostasis and diseases in which bone loss is a cardinal sign. The aim of this study was to determine whether chronic periodontal disease in a Brazilian population is associated with polymorphisms in the VDR gene. Methods: Clinical examination and recordings of probing depth and clinical attachment level were performed in 113 unrelated adults who were divided into two groups: 44 healthy individuals (control group) and 69 subjects with chronic periodontitis (CP). DNA was obtained from the subjects' epithelial cells by scraping the buccal mucosa. Two polymorphisms in the VDR gene were analyzed by polymerase chain reaction; followed by TaqI and BsmI restriction endonuclease digestion. Results: Frequencies of VDR/TaqI and VDR/BsmI showed significant differences between the control group and the CP group (P<0.05). The "Tb" haplotype was prevalent in the control group (43.2%), and the "TB" haplotype in the CP group (36.6%). The "TB" haplotype seemed to increase susceptibility to periodontal disease (odds ratio [OR] = 2.19). The heterozygous haplotype "TB/tb" was predominant in the CP group (OR = 4.32; P = 0.005). Conclusions: TaqI and BsmI polymorphisms of the VDR gene are associated with clinical attachment loss due to periodontal disease in a Brazilian population. These findings suggest that VDR genotype might be a risk indicator for susceptibility to chronic periodontitis.
dc.description75
dc.description8
dc.description1090
dc.description1095
dc.languageen
dc.publisherAmer Acad Periodontology
dc.publisherChicago
dc.publisherEUA
dc.relationJournal Of Periodontology
dc.relationJ. Periodont.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectBsmI polymerase
dc.subjectBrazil
dc.subjectperiodontal attachment loss/etiology
dc.subjectperiodontal diseases/etiology
dc.subjectpolymerase chain reaction
dc.subjectpolymorphism
dc.subjectgenetic
dc.subjectreceptors
dc.subjectvitamin D
dc.subjectrestriction endonucleases
dc.subjectrisk factors
dc.subjectTaqI polymerase
dc.subjectBone-mineral Density
dc.subjectEarly-onset Periodontitis
dc.subjectIncreased Risk
dc.subjectTooth Loss
dc.subjectAlleles
dc.subjectOsteoporosis
dc.subjectOsteocalcin
dc.subjectPopulation
dc.subjectGenotype
dc.titlePolymorphisms in the vitamin D receptor gene are associated with periodontal disease
dc.typeArtículos de revistas


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