Factors associated with HPV persistence after treatment for high-grade cervical intra-epithelial neoplasia with large loop excision of the transformation zone (LLETZ)

dc.creatorSarian, LOZ
dc.creatorDerchain, SFM
dc.creatorPitta, DD
dc.creatorMorais, SS
dc.creatorRabelo-Santos, SH
dc.date2004
dc.dateDEC
dc.date2014-11-19T01:41:11Z
dc.date2015-11-26T17:00:33Z
dc.date2014-11-19T01:41:11Z
dc.date2015-11-26T17:00:33Z
dc.date.accessioned2018-03-28T23:48:20Z
dc.date.available2018-03-28T23:48:20Z
dc.identifierJournal Of Clinical Virology. Elsevier Science Bv, v. 31, n. 4, n. 270, n. 274, 2004.
dc.identifier1386-6532
dc.identifierWOS:000225200300006
dc.identifier10.1016/j.jcv.2004.05.012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66681
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/66681
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66681
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278501
dc.descriptionBackground and objective: Human Papillomavirus (HPV) persistence after high-grade cervical intra-epithelial neoplasia (CIN) removal may be associated with residual lesions or risk of disease recurrence. Knowledge regarding the factors associated with HPV persistence following CIN treatment is still limited. The main purpose of this longitudinal study was to assess the association between characteristics of the patients and their cervical lesions with high-risk HPV-type persistence, detected by commercially available Hybrid Capture II (HC II), after CIN 2 and 3 treatment with large loop excision of the transformation zone (LLETZ). Study design: For this cohort study, a total of 94 women submitted to LLETZ between March 2001 and September 2002 were included. Only women with at least one follow-up visit at 6 or 12 months and confirmed CIN 2 or 3 in the cone specimen were considered. In each visit women answered to a questionnaire and undertook Pap smear and HC II specimens collection. McNemar's, chi-square and Fisher tests were used for univariate analysis. Generalized Estimating Equations (GEE) were used for multivariate analysis. All calculations were performed within 95% confidence intervals (95% CI). Results: Histological evaluation showed 12 (13%) women with CIN, 2 and 82 (87%) with CIN 3 and conization margins were compromised in 27 (29%) cases. Eighty-seven (92%) women showed positive HC II tests prior to LLETZ. Of women initially HPV negative, none had a positive HC II during follow-up. The proportion of positive HPV tests was reduced from 92% to 20%(P < 0.01) at the first visit and to 22% (P < 0.01) at the second visit after LLETZ. Multivariate analysis showed that smoking and age above 35 years (irrespective of margin status) were strongly associated with positive HPV during follow-up. Conclusion: HPV persistence following LLETZ was associated with smoking and with the interaction between age and conization margins. (C) 2004 Published by Elsevier B.V.
dc.description31
dc.description4
dc.description270
dc.description274
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationJournal Of Clinical Virology
dc.relationJ. Clin. Virol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjecthuman papillomavirus
dc.subjectclearance
dc.subjectage
dc.subjectsmoking
dc.subjecthybrid capture II
dc.subjectHuman-papillomavirus Infection
dc.subjectCold-knife Conization
dc.subjectElectrosurgical Excision
dc.subjectLongitudinal Data
dc.subjectNatural-history
dc.subjectDysplasia
dc.subjectLesions
dc.subjectColposcopy
dc.subjectClearance
dc.subjectSmoking
dc.titleFactors associated with HPV persistence after treatment for high-grade cervical intra-epithelial neoplasia with large loop excision of the transformation zone (LLETZ)
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución