Antiproliferative and Antifungal Activities of 1,3-diarylpropane-1,3-diones Commonly used as Sunscreen Agents

dc.creatorAbranches, PAD
dc.creatorda Silva, ED
dc.creatorVarejao, EVV
dc.creatorMartins, CVB
dc.creatorRuiz, ALTG
dc.creatorde Resende-Stoianoff, MA
dc.creatorde Carvalho, JE
dc.creatorde Fatima, A
dc.creatorFernandes, SA
dc.date2013
dc.dateAUG
dc.date2014-08-01T18:22:28Z
dc.date2015-11-26T16:59:51Z
dc.date2014-08-01T18:22:28Z
dc.date2015-11-26T16:59:51Z
dc.date.accessioned2018-03-28T23:47:35Z
dc.date.available2018-03-28T23:47:35Z
dc.identifierLetters In Drug Design & Discovery. Bentham Science Publ Ltd, v. 10, n. 7, n. 661, n. 665, 2013.
dc.identifier1570-1808
dc.identifierWOS:000320915500013
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77985
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77985
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278315
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionParsol 1789 and eusolex 8021 are two 1,3-diarylpropane-1,3-diones widely used as UV-absorbing agents in sunscreen formulations. Their chemical structures are quite similar to that of curcumin, a natural compound known to present a wide range of relevant pharmacological activities, including antifungal and anticancer activities. Such structural similarity, together with their availability and low cost sparked our interest for investigating their potential as antiproliferative and antifungal agents. Parsol and eusolex presented antiproliferative activity against eight human cancer cell lines. Promisingly, parsol was almost as active against the human lung cancer cell line NCI-ADR/RES (GI(50) 1.1 +/- 0.8 mu g mL(-1)) as the positive control doxorubicin (GI(50) 1.7 +/- 2.1 mu g mL(-1)). When tested for antifungal activity, parsol and eusolex showed activity comparable to that of fluconazole, the reference drug, against Paracoccidioides brasiliensis and Cryptococcus neoformans. Sporothrix schenckii was significantly more sensitive to parsol and eusolex (MIC = 16 mu g mL(-1), for both compounds) than fluconazole (MIC = 64 mu g mL(-1)).
dc.description10
dc.description7
dc.description661
dc.description665
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFUNARBE
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionFundacao Araucaria
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherBentham Science Publ Ltd
dc.publisherSharjah
dc.publisherEmirados Árabes Unidos
dc.relationLetters In Drug Design & Discovery
dc.relationLett. Drug Des. Discov.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectParsol
dc.subjectEusolex
dc.subjectCurcumin
dc.subjectAntifungal
dc.subjectAntiproliferative and Cancer cells
dc.subjectGoniothalamin Enantiomers
dc.subjectCurcumin Analogs
dc.subjectAntitumor Agents
dc.subjectCancer-cells
dc.subjectIn-vitro
dc.subjectDerivatives
dc.subjectInvolvement
dc.subjectPotencies
dc.subjectApoptosis
dc.subjectInducers
dc.titleAntiproliferative and Antifungal Activities of 1,3-diarylpropane-1,3-diones Commonly used as Sunscreen Agents
dc.typeArtículos de revistas


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