Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines

dc.creatorSavietto, JP
dc.creatorFurlan, CM
dc.creatorMotta, LB
dc.creatorSalatino, MLF
dc.creatorCarvalho, JE
dc.creatorRuiz, ALTG
dc.creatorSalatino, A
dc.creatorSantos, DYAC
dc.date2013
dc.dateJUL-AUG
dc.date2014-08-01T18:22:27Z
dc.date2015-11-26T16:59:50Z
dc.date2014-08-01T18:22:27Z
dc.date2015-11-26T16:59:50Z
dc.date.accessioned2018-03-28T23:47:35Z
dc.date.available2018-03-28T23:47:35Z
dc.identifierRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Soc Brasileira Farmacognosia, v. 23, n. 4, n. 662, n. 667, 2013.
dc.identifier0102-695X
dc.identifierWOS:000324927500013
dc.identifier10.1590/S0102-695X2013005000058
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77981
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77981
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278311
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionSeveral species of Croton have been described with biological activities, mainly due to diterpenes, alkaloids and/or other secondary metabolites. These activities account for the traditional use of Croton species to treat certain diseases in South America, Asia and Western Africa. The crude methanol extracts obtained from leaves and steam bark of Croton dichrous Mull. Arg., C. erythroxyloides Baill., C. myrianthus Mull. Arg. and C. splendidus Mart. ex Colla were tested for antiproliferative activity against ten human cancer cell lines. Chemical analyses of all extracts were carried out by GC/MS and HPLC/MS/MS. The leaf extract obtained from C. erythroxyloides showed potent activity against PC-3 (prostate) and OVCAR-3 (ovary) cell lines. Lupeol is suggested to be involved in such activity. Tiliroside, an acyl-glycosilated flavonoid ubiquitous in all tested extracts, seems to play an important role in the observed moderate activity of most extracts against the leukemia K562 cell lineage.
dc.description23
dc.description4
dc.description662
dc.description667
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [07/02518-6]
dc.languageen
dc.publisherSoc Brasileira Farmacognosia
dc.publisherCuritiba-pr
dc.publisherBrasil
dc.relationRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy
dc.relationRev. Bras. Farmacogn.-Braz. J. Pharmacogn.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectantiproliferative activity
dc.subjectCroton
dc.subjectEuphorbiaceae
dc.subjecthuman cell lines
dc.subjectlupeol
dc.subjectmethanol extract
dc.subjectAnticancer Drug Screen
dc.subjectIn-vitro
dc.subjectCancer-cells
dc.subjectPlants
dc.subjectAgents
dc.subjectEuphorbiaceae
dc.subjectInhibition
dc.subjectPlaunotol
dc.subjectCajucara
dc.titleAntiproliferative activity of methanol extracts of four species of Croton on different human cell lines
dc.typeArtículos de revistas


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