Antiproliferative activity and constituents of leaf extracts of Croton sphaerogynus Baill. (Euphorbiaceae)

dc.creatorMotta, LB
dc.creatorFurlan, CM
dc.creatorSantos, DYAC
dc.creatorSalatino, MLF
dc.creatorNegri, G
dc.creatorde Carvalho, JE
dc.creatorMonteiro, PA
dc.creatorRuiz, ALTG
dc.creatorCaruzo, MB
dc.creatorSalatino, A
dc.date2013
dc.dateOCT
dc.date2014-08-01T18:22:24Z
dc.date2015-11-26T16:59:49Z
dc.date2014-08-01T18:22:24Z
dc.date2015-11-26T16:59:49Z
dc.date.accessioned2018-03-28T23:47:33Z
dc.date.available2018-03-28T23:47:33Z
dc.identifierIndustrial Crops And Products. Elsevier Science Bv, v. 50, n. 661, n. 665, 2013.
dc.identifier0926-6690
dc.identifier1872-633X
dc.identifierWOS:000326903600088
dc.identifier10.1016/j.indcrop.2013.08.008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77960
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77960
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278306
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionSeveral Croton species have been used in traditional medicine and contain substances active against cancer, such as diterpenoids and alkaloids. Croton sphaerogynus is a shrub from the Atlantic Rain Forest in southeastern Brazil. The main goal of this study was to characterize the main constituents of the leaf extracts of C. sphaerogynus and evaluate their in vitro antiproliferative activity against tumor cell lines. Hexane, dichloromethane and methanol extracts of leaves were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on the cell lines 786-0 (kidney), HT-29 (colon), 1(562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). Relevant constituents in dichloromethane and hexane extracts were abietane, podocarpane and clerodane type furano diterpenes. Dicloromethane and hexane extracts exhibited activity against NCI-H460 (GI(50) 0.26 mu g/mL and 0.33 mu g/mL, respectively) and K562 (GI(50) 0.60 mu g/mL and <0.25 mu g/mL, respectively). Taking into account all cell lines tested, the dichloromethane extract was shown to have higher activity (mean log GI(50) 0.86) than hexane and methanol extracts (mean log GI(50) 1.26 and 1.49, respectively). The antiproliferative activity observed in the present work is probably accounted for by the abietane and/or podocarpane diterpenes. (C) 2013 Elsevier B.V. All rights reserved.
dc.description50
dc.description661
dc.description665
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationIndustrial Crops And Products
dc.relationInd. Crop. Prod.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectCroton sphaerogynus
dc.subjectEuphorbiaceae
dc.subjectAntiproliferative activity
dc.subjectDiterpenes
dc.subjectPodocarpanes
dc.subjectAbietanes
dc.subjectAnticancer Drug Screen
dc.subjectAbietane Diterpenes
dc.subjectCell-lines
dc.subjectLeaves
dc.subjectDerivatives
dc.subjectFractions
dc.subjectApoptosis
dc.titleAntiproliferative activity and constituents of leaf extracts of Croton sphaerogynus Baill. (Euphorbiaceae)
dc.typeArtículos de revistas


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