Volumetric Brain Changes in Thalamus, Corpus Callosum and Medial Temporal Structures: Mild Alzheimer's Disease Compared with Amnestic Mild Cognitive Impairment

dc.creatorPedro, T
dc.creatorWeiler, M
dc.creatorYasuda, CL
dc.creatorD'Abreu, A
dc.creatorDamasceno, BP
dc.creatorCendes, F
dc.creatorBalthazar, MLF
dc.date2012
dc.date2014-08-01T18:15:59Z
dc.date2015-11-26T16:59:32Z
dc.date2014-08-01T18:15:59Z
dc.date2015-11-26T16:59:32Z
dc.date.accessioned2018-03-28T23:47:12Z
dc.date.available2018-03-28T23:47:12Z
dc.identifierDementia And Geriatric Cognitive Disorders. Karger, v. 34, n. 41732, n. 149, n. 155, 2012.
dc.identifier1420-8008
dc.identifierWOS:000312897800002
dc.identifier10.1159/000342118
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76230
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76230
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278214
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: It is widely known that atrophy of medial temporal structures is present in the mild stage of Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However, structures such as the thalamus and corpus callosum are much less studied. Methods: We compared the volumes of the entorhinal cortex, hippocampus, thalamus and the corpus callosum in 14 controls, 14 patients with mild AD and 15 with aMCI and correlated these volumes with neuropsychological data. MRI was obtained at 2 T followed by manual segmentation. Results: We found atrophy in hippocampi and thalami of MCI patients compared to controls, and in the bilateral entorhinal cortex of aMCI compared to AD patients. All the structures showed atrophy in AD patients compared to controls, including the corpus callosum. Conclusions: Our study confirms that thalamic areas are atrophied in aMCI, and the corpus callosum might represent a good structural marker for mild AD. Those areas were associated with cognitive functions already described in the literature. Copyright (C) 2012 S. Karger AG, Basel
dc.description34
dc.description41732
dc.description149
dc.description155
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2009/02179-2]
dc.languageen
dc.publisherKarger
dc.publisherBasel
dc.publisherSuíça
dc.relationDementia And Geriatric Cognitive Disorders
dc.relationDement. Geriatr. Cogn. Disord.
dc.rightsfechado
dc.rightshttp://www.karger.com/Services/RightsPermissions
dc.sourceWeb of Science
dc.subjectAlzheimer's disease
dc.subjectAmnestic mild cognitive impairment
dc.subjectThalamus
dc.subjectCorpus callosum
dc.subjectVolumetry
dc.subjectVoxel-based Morphometry
dc.subjectGray-matter Loss
dc.subjectEntorhinal Cortex
dc.subjectDementia
dc.subjectAtrophy
dc.subjectMri
dc.subjectHippocampus
dc.subjectDecline
dc.subjectDegeneration
dc.subjectPattern
dc.titleVolumetric Brain Changes in Thalamus, Corpus Callosum and Medial Temporal Structures: Mild Alzheimer's Disease Compared with Amnestic Mild Cognitive Impairment
dc.typeArtículos de revistas


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