Voltammetric method optimized by multi-response assays for the simultaneous measurements of uric acid and acetaminophen in urine in the presence of surfactant using MWCNT paste electrode

dc.creatorHudari, FF
dc.creatorDuarte, EH
dc.creatorPereira, AC
dc.creatorDall'Antonia, LH
dc.creatorKubota, LT
dc.creatorTarley, CRT
dc.date2013
dc.dateMAY 1
dc.date2014-08-01T18:15:58Z
dc.date2015-11-26T16:59:31Z
dc.date2014-08-01T18:15:58Z
dc.date2015-11-26T16:59:31Z
dc.date.accessioned2018-03-28T23:47:11Z
dc.date.available2018-03-28T23:47:11Z
dc.identifierJournal Of Electroanalytical Chemistry. Elsevier Science Sa, v. 696, n. 52, n. 58, 2013.
dc.identifier1572-6657
dc.identifierWOS:000319308800008
dc.identifier10.1016/j.jelechem.2013.01.033
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76225
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76225
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278209
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionIn the present study, an electroanalytical method for the simultaneous determination of acetaminophen (AC) and uric acid (UA) in urine samples with a carbon nanotube paste electrode (CNTPE) employing a cationic surfactant (cetylpyridinium bromide, CPB) was developed. The optimization of the proposed differential pulse voltammetric method was performed by means of multi-response assays, highly recommended for simultaneous analysis. Under optimized conditions (pH 7.7, phosphate concentration of 0.1 mol L-1, pulse amplitude of 123 mV, modulation time of 5 ms, CPB concentration of 0.30 mmol L-1 and scan rate of 100 mV s(-1)), a remarkable peak separation of UA and AC at 174 mV was achieved. The linear curves for the simultaneous determination of UA and AC were built in concentration range of 5.0-92.6 mu mol L-1 with satisfactory regression of 0.995 for UA and 0.999 for AC. Limits of detection were found to be 0.25 and 0.57 mu mol L-1 for UA and AC, respectively, and the precision assessed as relative standard deviation (RSD) for ten determinations was found to be 3.20% and 1.34% for respective concentrations of 10.0 and 72.5 mu mol L-1 for UA and 4.3% and 1.6% for AC. The electrochemical sensor with antifouling features was successfully applied for the free-interference simultaneous determination of UA and AC in urine samples. (C) 2013 Elsevier B.V. All rights reserved.
dc.description696
dc.description52
dc.description58
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUEL (Universidade Estadual de Londrina)
dc.descriptionINCT for Bianalytics (Instituto Nacional de Ciencia e Tecnologia de Bioanalitica)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherElsevier Science Sa
dc.publisherLausanne
dc.publisherSuíça
dc.relationJournal Of Electroanalytical Chemistry
dc.relationJ. Electroanal. Chem.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectCarbon nanotubes
dc.subjectFactorial design
dc.subjectVoltammetric sensor
dc.subjectUrine samples
dc.subjectUric acid
dc.subjectParacetamol
dc.subjectGlassy-carbon Electrode
dc.subjectAscorbic-acid
dc.subjectParacetamol
dc.subjectSensor
dc.subjectDopamine
dc.titleVoltammetric method optimized by multi-response assays for the simultaneous measurements of uric acid and acetaminophen in urine in the presence of surfactant using MWCNT paste electrode
dc.typeArtículos de revistas


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