Time-Course Analyses Addressing the Acquisition of DBA Lectin Reactivity in Mouse Lymphoid Organs and Uterus During the First Week of Pregnancy

dc.creatorBianco, J
dc.creatorStephenson, K
dc.creatorYamada, AT
dc.creatorCroy, BA
dc.date2008
dc.dateDEC
dc.date2014-08-01T18:22:14Z
dc.date2015-11-26T16:59:27Z
dc.date2014-08-01T18:22:14Z
dc.date2015-11-26T16:59:27Z
dc.date.accessioned2018-03-28T23:47:06Z
dc.date.available2018-03-28T23:47:06Z
dc.identifierPlacenta. W B Saunders Co Ltd, v. 29, n. 12, n. 1009, n. 1015, 2008.
dc.identifier0143-4004
dc.identifierWOS:000261910600004
dc.identifier10.1016/j.placenta.2008.09.007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77868
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77868
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278190
dc.descriptionTerminal differentiation of uterine natural killer (uNK) cells is induced in humans and mice at the time of endometrial decidualization. in mice, commitment to this lineage is first recognized at gestation day (gd)5.5 when small, non-granulated lymphocytes in the mesometrial decidua basalis become histochemically reactive with the lectin Dolichlos biflorus agglutinin (DBA). Transplantation experiments in mice have shown that the self-renewing progenitors of uNK cells are present in peripheral rather than uterine tissues. While lymphoid tissues of virgin mice lack DBA lectin reactive putative uNK cell precursors or progenitors, peripheral organs have not been systematically examined in female mice during early pregnancy while the uNK cell population is becoming established. Here we report Such a study in gd0.5-7.5 random bred mice. Only mesenteric lymph nodes showed a transient gain in DBA lectin reactive lymphocytes between gd0.5 and 4.5. These cells had cytoplasmic but almost no surface DBA lectin reactivity. This study indicates that the decidual environment is unique and locally promotes DBA lectin surface expression in terminally differentiating uNK cells. (c) 2008 Elsevier Ltd. All rights reserved.
dc.description29
dc.description12
dc.description1009
dc.description1015
dc.descriptionNSERC
dc.descriptionCanada Research Chairs Program
dc.languageen
dc.publisherW B Saunders Co Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationPlacenta
dc.relationPlacenta
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectDecidua
dc.subjectLymphoid organs
dc.subjectLymphocyte differentiation
dc.subjectUterine natural killer cells
dc.subjectUterus
dc.subjectNatural-killer-cells
dc.subjectMetrial Gland-cells
dc.subjectNk Cells
dc.subjectHuman Endometrium
dc.subjectExpression
dc.subjectMice
dc.subjectAngiogenesis
dc.subjectLymphocytes
dc.subjectPopulation
dc.subjectConceptus
dc.titleTime-Course Analyses Addressing the Acquisition of DBA Lectin Reactivity in Mouse Lymphoid Organs and Uterus During the First Week of Pregnancy
dc.typeArtículos de revistas


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