In utero and lactational exposure to fenvalerate disrupts reproductive function in female rats

dc.creatorGuerra, MT
dc.creatorde Toledo, FC
dc.creatorKempinas, WDG
dc.date2011
dc.dateNOV
dc.date2014-07-30T18:01:58Z
dc.date2015-11-26T16:59:25Z
dc.date2014-07-30T18:01:58Z
dc.date2015-11-26T16:59:25Z
dc.date.accessioned2018-03-28T23:47:04Z
dc.date.available2018-03-28T23:47:04Z
dc.identifierReproductive Toxicology. Pergamon-elsevier Science Ltd, v. 32, n. 3, n. 298, n. 303, 2011.
dc.identifier0890-6238
dc.identifierWOS:000296935100007
dc.identifier10.1016/j.reprotox.2011.08.002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69328
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69328
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278181
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFenvalerate is a synthetic pyrethroid insecticide used in agriculture and domestic insect control. Some studies have proposed that it may act as an environmental estrogen; other studies suggest possible genotoxicity in germ cells. This study aimed to evaluate the effects of fenvalerate on the female reproduction in rats whose mothers were exposed during gestation and lactation. Pregnant Wistar rats were exposed to fenvalerate (40 mg/kg) or corn oil (vehicle) orally from gestational day 12 until the end of lactation. The dose selection was based on previous studies, whereas this was considered an effective dose. Results showed decreases in ovarian weight, pre-antral follicles and corpora lutea at PND 75 and an increase in the resorption number, when fertility test was performed at PND 80. Under some experimental conditions, fenvalerate may impair reproductive development of female offspring, manifested as reduced fecundity and ovulation number, resulting from the impairment in corpora lutea counting. (C) 2011 Elsevier Inc. All rights reserved.
dc.description32
dc.description3
dc.description298
dc.description303
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionNational Council for Scientific and Technological Development (CNN)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [06/60373-1]
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationReproductive Toxicology
dc.relationReprod. Toxicol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectFenvalerate
dc.subjectFemale reproduction
dc.subjectToxicology
dc.subjectEstrous cycle
dc.subjectOvaries
dc.subjectPesticide Factory-workers
dc.subjectPyrethroid Insecticides
dc.subjectSynthetic Pyrethroids
dc.subjectChemicals
dc.subjectVitro
dc.subjectHormone
dc.subjectHealth
dc.subjectEsfenvalerate
dc.subjectEstrogen
dc.subjectReceptor
dc.titleIn utero and lactational exposure to fenvalerate disrupts reproductive function in female rats
dc.typeArtículos de revistas


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