Assessment of Female Reproductive Endpoints in Sprague-Dawley Rats Developmentally Exposed to Diuron: Potential Ovary Toxicity

dc.creatorGrassi, TF
dc.creatorGuerra, MT
dc.creatorPerobelli, JE
dc.creatorde Toledo, FC
dc.creatorda Silva, DS
dc.creatorKempinas, WD
dc.creatorBarbisan, LF
dc.date2011
dc.dateOCT
dc.date2014-07-30T13:51:06Z
dc.date2015-11-26T16:58:57Z
dc.date2014-07-30T13:51:06Z
dc.date2015-11-26T16:58:57Z
dc.date.accessioned2018-03-28T23:46:37Z
dc.date.available2018-03-28T23:46:37Z
dc.identifierBirth Defects Research Part B-developmental And Reproductive Toxicology. Wiley-blackwell, v. 92, n. 5, n. 478, n. 486, 2011.
dc.identifier1542-9733
dc.identifierWOS:000296612100008
dc.identifier10.1002/bdrb.20317
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54982
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54982
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278067
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBACKGROUND: Diuron is widely used in agriculture but its deleterious effects on the reproductive system and mammary gland are still poorly understood. This study evaluated whether early-life-stage exposure to Diuron alters puberty onset or susceptibility to mammary carcinogenesis in female Sprague-Dawley rats. METHODS AND RESULTS: Pregnant rats received basal diet or diet containing Diuron at 500, 750, and 1,250 ppm, from gestational day 12 to the end of lactation (postnatal day 21 [PND21]). After weaning, female offspring continued receiving basal diet or diet containing Diuron until PND 51. At PND 51, female Sprague-Dawley offspring received a single dose of 50 mg/kg b.w. of 7,12-dimethylbenz(a) anthracene (DMBA) for initiation of mammary carcinogenesis. The animals were sacrificed on PND 51, 75, and 226 to 233 (week 25) for mammary gland morphology, reproductive organs and tumor analysis, respectively. There were no significant differences among groups on vaginal opening, estrous cycle, mammary morphology, or carcinogenesis. However, reductions in ovary weight and corpora lutea were observed at PND 75 in the group treated with Diuron at 1,250 ppm. CONCLUSIONS: The findings suggesting that Diuron exposure (1,250 ppm) may have been potentially toxic to the ovaries. Birth Defects Res (Part B) 92:478-486, 2011. (C) 2011 Wiley Periodicals, Inc.
dc.description92
dc.description5
dc.descriptionSI
dc.description478
dc.description486
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2006/01330-0]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationBirth Defects Research Part B-developmental And Reproductive Toxicology
dc.relationBirth Defects Res. Part B-Dev. Reprod. Toxicol.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectdiuron
dc.subjectmaternal exposure
dc.subjectfemale offspring
dc.subjectreproduction
dc.subjectmammary carcinogenesis
dc.subjectSprague-Dawley rats
dc.subjectIn-vitro
dc.subjectEstrogen-receptor
dc.subjectMammary-gland
dc.subjectPesticides
dc.subjectUrine
dc.subjectMetabolites
dc.subjectAtrazine
dc.subjectCarcinogenesis
dc.subjectPhenylurea
dc.subjectChemicals
dc.titleAssessment of Female Reproductive Endpoints in Sprague-Dawley Rats Developmentally Exposed to Diuron: Potential Ovary Toxicity
dc.typeArtículos de revistas


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