A leucine-rich diet and exercise affect the biomechanical characteristics of the digital flexor tendon in rats after nutritional recovery

dc.creatorBarbosa, AWC
dc.creatorBenevides, GP
dc.creatorAlferes, LMT
dc.creatorSalomao, EM
dc.creatorGomes-Marcondes, MCC
dc.creatorGomes, L
dc.date2012
dc.dateJAN
dc.date2014-08-01T18:14:43Z
dc.date2015-11-26T16:58:29Z
dc.date2014-08-01T18:14:43Z
dc.date2015-11-26T16:58:29Z
dc.date.accessioned2018-03-28T23:46:05Z
dc.date.available2018-03-28T23:46:05Z
dc.identifierAmino Acids. Springer, v. 42, n. 1, n. 329, n. 336, 2012.
dc.identifier0939-4451
dc.identifierWOS:000298644600028
dc.identifier10.1007/s00726-010-0810-1
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76006
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76006
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1277933
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAn increase in the capacity of athletic performance depends on adequate nutrition, which ensures optimal function of the musculoskeletal system, including tendon stability. However, little is known about the status of tendons and extracellular matrix modifications during malnutrition and nutritional recovery when leucine is used in response to exercise conditioning. The purpose of this study was to evaluate the collagen content and biomechanical aspects of the deep digital flexor tendon (DDFT) in malnourished rats submitted to nutritional recovery (control diet or leucine-rich diet) and aerobic physical activity. After 60 days of undernourishment (6% protein diet), the malnourished rats were subsequently nutritionally recovered with a control diet or leucine-rich diet and trained or not (swimming, without overload) for 5 weeks. The biomechanical analysis and quantification of hydroxyproline were assessed in the DDFT in all experimental groups. The leucine-rich diet increased hydroxyproline content in the tension region, independently of the training. In the compression region, hydroxyproline content was higher in the malnourished and leucine-trained groups. Biomechanical analysis showed a lower load in the malnourished and all-trained groups. The lowest stress was observed with control-trained animals. The nutritional-recovered groups showed higher strain values corresponding to control group, while the lowest values were observed in malnourished and trained groups. The results suggest that a leucine-rich diet stimulates collagen synthesis of the DDFT, especially when in combination with physical exercise, and seems to determine the increase of resistance and the biomechanical characteristics of tendons.
dc.description42
dc.description1
dc.description329
dc.description336
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [04/00514-5, 01/2135-3]
dc.descriptionCNPq [304000/2007-8, 502915/2007-2]
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationAmino Acids
dc.relationAmino Acids
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectLeucine
dc.subjectAerobic exercise
dc.subjectExtracellular matrix
dc.subjectTendon
dc.subjectNutrition
dc.subjectExtracellular-matrix
dc.subjectCollagen Fibrillogenesis
dc.subjectCalcaneal Tendon
dc.subjectBody-composition
dc.subjectSkeletal-muscle
dc.subjectProteoglycans
dc.subjectSupplementation
dc.subjectFibromodulin
dc.subjectRestriction
dc.subjectMetabolism
dc.titleA leucine-rich diet and exercise affect the biomechanical characteristics of the digital flexor tendon in rats after nutritional recovery
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución