Heteropterys aphrodisiaca infusion reduces the collateral effects of cyclosporine A on the testis

dc.creatorMonteiro, JC
dc.creatorPredes, FS
dc.creatorMatta, SLP
dc.creatorDolder, H
dc.date2008
dc.dateJUL
dc.date2014-11-18T19:36:27Z
dc.date2015-11-26T16:58:10Z
dc.date2014-11-18T19:36:27Z
dc.date2015-11-26T16:58:10Z
dc.date.accessioned2018-03-28T23:45:47Z
dc.date.available2018-03-28T23:45:47Z
dc.identifierAnatomical Record-advances In Integrative Anatomy And Evolutionary Biology. Wiley-liss, v. 291, n. 7, n. 809, n. 817, 2008.
dc.identifier1932-8486
dc.identifierWOS:000257333600008
dc.identifier10.1002/ar.20709
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68299
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/68299
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68299
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1277857
dc.descriptionCyclosporine A (CsA) is known to have testicular toxicity, leading to male infertility. Stimulant and aphrodisiac properties have been attributed to the plant, Heteropterys aphrodisiaca. Thus, the present work was undertaken to evaluate the association of the drug and the medicinal herb in Wistar rats, applying testicular morphometry and ultrastructure. Twenty-four rats were used, divided into four groups: I, control; II, CsA; III, simultaneous use of CsA and H. aphrodisiaca; IV, H. aphrodisiaca. Daily administration by gavage was carried out, during 56 days, of water (sham), CsA in a dose of 15 mg/kg per day and/or H. aphrodisiaca in a dose of 0.5 ml of the infusion prepared with 25 g of roots/100 ml of boiling water. Increased body weight was observed for all groups, but the animals that received only CsA showed the smallest body weight gain. Morphometry showed increased connective tissue volumetric proportion and decreased Leydig cell volumetric proportion in CsA-treated rats. Using transmission electron microscopy, it was possible to ascertain that CsA caused seminiferous epithelium degeneration, resulting in Sertoli cell vacuolization, abnormal round and elongated spermatids and large accumulation of residual cytoplasm at the epithelium border next to the lumen. Expanded intercellular spaces between germ cells were still observed in H. aphrodisiaca-treated rat testes. The administration of H. aphrodisiaca infusion to CsA-treated rats diminished nearly all the CsA-induced damage to the testis ultrastruclure, suggesting that H. aphrodisiaca infusion may be used combined with CsA to reduce CsA-induced injuries in the testis.
dc.description291
dc.description7
dc.description809
dc.description817
dc.languageen
dc.publisherWiley-liss
dc.publisherHoboken
dc.publisherEUA
dc.relationAnatomical Record-advances In Integrative Anatomy And Evolutionary Biology
dc.relationAnat. Rec.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcyclosporine
dc.subjectHeteropterys aphrodisiaca
dc.subjectWistar rats
dc.subjecttestes
dc.subjectmorphometry
dc.subjectultrastructure
dc.subjectRat Testis
dc.subjectMale Reproduction
dc.subjectLeydig-cells
dc.subjectSpermatogenesis
dc.subjectMechanism
dc.subjectProtects
dc.titleHeteropterys aphrodisiaca infusion reduces the collateral effects of cyclosporine A on the testis
dc.typeArtículos de revistas


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