Suramin affects metalloproteinase-9 activity and increases beta-dystroglycan levels in the diaphragm of the dystrophin-deficient mdx MOUSE

dc.creatorTaniguti, APT
dc.creatorMatsumura, CY
dc.creatorRodrigues-Simioni, L
dc.creatorNeto, HS
dc.creatorMarques, MJ
dc.date2012
dc.dateNOV
dc.date2014-07-30T20:07:09Z
dc.date2015-11-26T16:57:59Z
dc.date2014-07-30T20:07:09Z
dc.date2015-11-26T16:57:59Z
dc.date.accessioned2018-03-28T23:45:37Z
dc.date.available2018-03-28T23:45:37Z
dc.identifierMuscle & Nerve. Wiley-blackwell, v. 46, n. 5, n. 810, n. 813, 2012.
dc.identifier0148-639X
dc.identifierWOS:000309751500019
dc.identifier10.1002/mus.23468
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74845
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74845
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1277825
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIntroduction: In Duchenne muscular dystrophy and in the mdx mouse, muscle fiber degeneration and subsequent fibrosis lead to cardiorespiratory failure. Previously, we demonstrated that the anti-fibrotic agent suramin was effective in decreasing fibrosis in mdx muscles. In this study, we were interested to see whether suramin could affect metalloproteinases (MMP) and improve the functional activity of the mdx diaphragm muscle. Methods: Zymography was performed to evaluate MMP-2 and MMP-9 activity. Western blotting was used to analyze the levels of beta-dystroglycan. Muscle function was assessed in hemidiaphragm in vitro preparations. Results: We found that suramin affects metalloproteinase-9 activity and increases beta-dystroglycan. Furthermore, suramin also protects against diaphragm muscle fatigue over time. Conclusions: These results show the potential benefits of suramin in maintaining the structure of the dystrophin-glycoprotein complex. Muscle Nerve, 46:810813, 2012
dc.description46
dc.description5
dc.description810
dc.description813
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [08/58491-1, 11/51697-6]
dc.descriptionCNPq [301306/2010-9, 302006/2009-5, 474708/06-3]
dc.descriptionCNPq [140557/07-5]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectbeta-dystroglycan
dc.subjectDMD
dc.subjectmdx
dc.subjectmetalloproteinases
dc.subjectsuramin
dc.subjectDuchenne Muscular-dystrophy
dc.subjectMessenger-rna Expression
dc.subjectSkeletal-muscle
dc.subjectMatrix Metalloproteinases
dc.subjectTransforming Growth-factor-beta-1
dc.subjectExtracellular-matrix
dc.subjectMice
dc.subjectMatrix-metalloproteinase-9
dc.subjectLocalization
dc.subjectRegeneration
dc.titleSuramin affects metalloproteinase-9 activity and increases beta-dystroglycan levels in the diaphragm of the dystrophin-deficient mdx MOUSE
dc.typeArtículos de revistas


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