Cytotoxic activity of (S)-goniothalamin and analogues against human cancer cells

dc.creatorde Fatima, A
dc.creatorKohn, LK
dc.creatorde Carvalho, JE
dc.creatorPilli, RA
dc.date2006
dc.dateFEB 1
dc.date2014-11-18T17:57:16Z
dc.date2015-11-26T16:57:36Z
dc.date2014-11-18T17:57:16Z
dc.date2015-11-26T16:57:36Z
dc.date.accessioned2018-03-28T23:45:10Z
dc.date.available2018-03-28T23:45:10Z
dc.identifierBioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 14, n. 3, n. 622, n. 631, 2006.
dc.identifier0968-0896
dc.identifier1464-3391
dc.identifierWOS:000234091700003
dc.identifier10.1016/j.bmc.2005.08.036
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57622
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57622
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57622
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1277709
dc.description(R)- and (S)-Goniothalamin (1) and analogues 2-9 were efficiently prepared in high overall yield and enantiomeric purity, and their cytotoxic activities were evaluated against eight human cancer cell lines. A structure-activity relationship study (SAR) allowed us to establish the relevant structural features for the cytotoxic activity of goniothalamin analogues. In addition, we have identified non-natural form of goniothalamin (S)-1 and analogue 5 as the highest and more selective cytotoxic compounds against kidney cancer cell growth (786-0) with IC50 = 4 and 5 nM, respectively, and compound 8 (IC50 = 4 nM) as the more potent against breast cancer cells with resistance phenotype for adryamycin (c) 2005 Elsevier Ltd. All rights reserved.
dc.description14
dc.description3
dc.description622
dc.description631
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationBioorganic & Medicinal Chemistry
dc.relationBioorg. Med. Chem.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subject(R)- and (S)-goniothalamin
dc.subjectstyryl lactones
dc.subjectcytotoxic activity
dc.subjectcancer cell lines
dc.subjectCatalytic Asymmetric Allylation
dc.subjectStyryl-lactone Derivatives
dc.subjectChiral Lewis-acid
dc.subjectBis(((s)-binaphthoxy)(isopropoxy)titanium) Oxide
dc.subjectUnsaturated Lactone
dc.subjectConjugate Reduction
dc.subjectGoniothalamin
dc.subjectLines
dc.subject(r)-argentilactone
dc.subject(r)-goniothalamin
dc.titleCytotoxic activity of (S)-goniothalamin and analogues against human cancer cells
dc.typeArtículos de revistas


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