Statins induce biochemical changes in the Achilles tendon after chronic treatment

dc.creatorde Oliveira, LP
dc.creatorVieira, CP
dc.creatorGuerra, FDR
dc.creatorde Almeida, MD
dc.creatorPimentel, ER
dc.date2013
dc.dateSEP 15
dc.date2014-07-30T20:02:45Z
dc.date2015-11-26T16:57:28Z
dc.date2014-07-30T20:02:45Z
dc.date2015-11-26T16:57:28Z
dc.date.accessioned2018-03-28T23:45:02Z
dc.date.available2018-03-28T23:45:02Z
dc.identifierToxicology. Elsevier Ireland Ltd, v. 311, n. 3, n. 162, n. 168, 2013.
dc.identifier0300-483X
dc.identifierWOS:000324609200009
dc.identifier10.1016/j.tox.2013.06.010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74566
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74566
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1277675
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionStatins have been widely prescribed as lipid-lowering drugs and are associated with tendon rupture. Therefore, this study aimed to evaluate the possible biochemical changes in the Achilles tendon of rats after chronic treatment with statins. Dosages of statins were calculated using allometric scaling with reference to the 80 mg/day and 20 mg/day, doses recommended for humans. The rats were divided into the following groups: treated with simvastatin (S-20 and S-80), treated with atorvastatin (A-20 and A-0), and the control group that received no treatment (C). Measurements of low-density lipoprotein (LDL) in the plasma were performed. The levels of non-collagenous proteins, glycosaminoglycans (GAGS) and hydroxyproline were quantified. Western blotting for collagen I was performed, and the presence of metalloproteinases (MMP5)-2 and -9 was investigated through zymography. The concentration of non-collagenous proteins in S-20 was less than the C group. There was a significant increase in pro-MMP-2 activity in A-80 group and in active MMP-2 in S-20 group compared to the C group. A significant increase in latent MMP-9 activity was observed in both the A-80 and S-20 groups when compared to C group. In the A-20 group, there was a lower amount of collagen I in relation to C group. In addition, a higher concentration of hydroxyproline was found in the S-20 group than the C group. The analysis of GAGs showed a significant increase in the A-20 group when compared to C group. The treatment induced remarkable alterations in the Achilles tendon and the response of the tissue seems to depend of the used statin dosage. The presence of MMP-2 and MMP-9 is evidence of the degradation and remodeling processes in the extracellular matrix of the tendons. Our results show that statins induce imbalance of extracellular matrix components and possibly induce microdamage in tendons. (C)13 Elsevier Ireland Ltd. All rights reserved.
dc.description311
dc.description3
dc.description162
dc.description168
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationToxicology
dc.relationToxicology
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectSimvastatin
dc.subjectAtorvastatin
dc.subjectCollagen
dc.subjectExtracellular matrix
dc.subjectMatrix Metalloproteinases
dc.subjectExtracellular-matrix
dc.subjectSmooth-muscle
dc.subjectSimvastatin
dc.subjectRupture
dc.subjectRats
dc.subjectAtorvastatin
dc.subjectMmp-9
dc.subjectProteoglycans
dc.subjectTendinopathy
dc.titleStatins induce biochemical changes in the Achilles tendon after chronic treatment
dc.typeArtículos de revistas


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