Moderate hyperalphalipoproteinaemia in a Brazilian population is related to lipoprotein lipase activity, apolipoprotein A-I concentration, age and body mass index

dc.creatorAlarcon, SBK
dc.creatorOliveira, HCF
dc.creatorHarada, LM
dc.creatorNunes, VS
dc.creatorKaplan, D
dc.creatorQuintao, ECR
dc.creatorde Faria, EC
dc.date2004
dc.dateJAN
dc.date2014-11-18T15:38:26Z
dc.date2015-11-26T16:56:22Z
dc.date2014-11-18T15:38:26Z
dc.date2015-11-26T16:56:22Z
dc.date.accessioned2018-03-28T23:43:48Z
dc.date.available2018-03-28T23:43:48Z
dc.identifierClinical Science. Portland Press, v. 106, n. 1, n. 11, n. 17, 2004.
dc.identifier0143-5221
dc.identifierWOS:000187957400003
dc.identifier10.1042/CS20030193
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/82352
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/82352
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/82352
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1277359
dc.descriptionWe investigated 95 Brazilian adults, aged 21-79 years, who were divided into two groups defined as having high-density lipoprotein (HDL)-cholesterol concentrations above [hyperalphalipoproteinaemia (HALP); n = 48] or below (controls; n = 47) the 90th percentile of a local population. The activities of lipid transfer proteins and enzymes involved in the plasma reverse cholesterol transport and the prevalence of factors that modulate HIDL metabolism (alcohol consumption, ponderosity, physical exercise, menopause and use of hormone replacement treatment in women and smoking) were measured, as well as the prevalence of cardiovascular disease and of its various risk factors. The two groups showed no differences in their frequencies of cardiovascular disease. The HDL2/H D L-3-cholesterol and triacylglycerol (triglyceride) ratios and the activities of the phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) were similar in both groups. Lipoprotein lipase (LPL) and hepatic lipase (HL) activities were 35% higher (P=0.0002) and 40% lower (P=0.0006) respectively, in HALP compared with control subjects. In a multivariate analysis, HDL-cholesterol and its subfractions were influenced by LPL, apolipoprotein A-I, age (negative relationship) and body mass index (negative relationship). Use of alcohol and ponderosity, as well as the interaction of these factors, explained the LPL activity. HIL activity was modulated by smoking, and hormone-replacement therapy influenced the apolipoprotein A-I concentration. CETP activity was influenced by race and PLTP by age. The unique phenotype found in this Brazilian HALP population, namely low HIL and high LPL activities, could be determined mostly by genetic components, on which future work will focus.
dc.description106
dc.description1
dc.description11
dc.description17
dc.languageen
dc.publisherPortland Press
dc.publisherLondon
dc.publisherInglaterra
dc.relationClinical Science
dc.relationClin. Sci.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectatherosclerotic cardiovascular disease
dc.subjectcholesteryl ester transfer protein (CETP)
dc.subjecthyperalphalipoproteinaemia
dc.subjecthepatic lipase
dc.subjectlipoprotein lipase
dc.subjectphospholipid transfer protein
dc.subjectHigh-density-lipoprotein
dc.subjectEster Transfer Protein
dc.subjectCoronary-heart-disease
dc.subjectSerum-lipid Levels
dc.subjectPlasma-lipoprotein
dc.subjectHepatic Lipases
dc.subjectAlcohol Intake
dc.subjectAmerican Men
dc.subjectCholesterol
dc.subjectHdl
dc.titleModerate hyperalphalipoproteinaemia in a Brazilian population is related to lipoprotein lipase activity, apolipoprotein A-I concentration, age and body mass index
dc.typeArtículos de revistas


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