Characterization of the inclusion complex ropivacaine: beta-cyclodextrin

dc.creatorFraceto, LF
dc.creatorGoncalves, MM
dc.creatorMoraes, CM
dc.creatorde Araujo, DR
dc.creatorZanella, L
dc.creatorde Paula, E
dc.creatorPertinhez, TDA
dc.date2007
dc.dateSEP-OCT
dc.date2014-11-18T14:49:05Z
dc.date2015-11-26T16:56:00Z
dc.date2014-11-18T14:49:05Z
dc.date2015-11-26T16:56:00Z
dc.date.accessioned2018-03-28T23:43:28Z
dc.date.available2018-03-28T23:43:28Z
dc.identifierQuimica Nova. Soc Brasileira Quimica, v. 30, n. 5, n. 1203, n. 1207, 2007.
dc.identifier0100-4042
dc.identifierWOS:000249501000028
dc.identifier10.1590/S0100-40422007000500028
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62905
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/62905
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62905
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1277275
dc.descriptionRopivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with beta-cyclodextrin (beta-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:beta-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:beta-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of beta-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.
dc.description30
dc.description5
dc.description1203
dc.description1207
dc.languagept
dc.publisherSoc Brasileira Quimica
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationQuimica Nova
dc.relationQuim. Nova
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectropivacame
dc.subjectcyclodextrin
dc.subjectNMR
dc.subjectLocal-anesthetics
dc.subjectNmr-spectroscopy
dc.subjectPhospholipid-bilayers
dc.subjectGamma-cyclodextrin
dc.subjectAqueous-solution
dc.subjectH-1-nmr
dc.subjectDrugs
dc.subjectAlpha
dc.subjectBupivacaine
dc.subjectResolution
dc.titleCharacterization of the inclusion complex ropivacaine: beta-cyclodextrin
dc.typeArtículos de revistas


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