Simultaneous determination of first-line anti-tuberculosis drugs by capillary zone electrophoresis using direct UV detection

dc.creatorFaria, AF
dc.creatorde Souza, MVN
dc.creatorBruns, RE
dc.creatorde Oliveira, MAL
dc.date2010
dc.date11110
dc.date2014-11-18T14:18:30Z
dc.date2015-11-26T16:55:50Z
dc.date2014-11-18T14:18:30Z
dc.date2015-11-26T16:55:50Z
dc.date.accessioned2018-03-28T23:43:15Z
dc.date.available2018-03-28T23:43:15Z
dc.identifierTalanta. Elsevier Science Bv, v. 82, n. 1, n. 333, n. 339, 2010.
dc.identifier0039-9140
dc.identifierWOS:000279488900048
dc.identifier10.1016/j.talanta.2010.04.044
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74204
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/74204
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74204
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1277225
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionAn alternative methodology for simultaneous analysis of ethambutol, isoniazid, rifampicin and pyrazinamide in pharmaceutical formulations by capillary zone electrophoresis under UV direct detection with an analysis time of 8.0 min is proposed. Background running was based on the effective mobility curve of the analytes and an optimum separation condition was achieved using a 3(3) Box-Behnken design, with Brij 35, Cu(2+) and acetic acid/sodium acetate buffer as factors. An electrolyte consisting of 50.0 mmol L(-1) of acetic acid/sodium acetate buffer:12.5 mmol L(-1) of CuSO(4), and standard and sample solutions prepared in 2.00 mmol L(-1) of Brij 35 and 12.5 mmol L(-1) of CuSO(4) were optimized. After evaluating validation parameters, the method was successfully applied to the analysis of samples in the form of tablets and sachets. (C) 2010 Elsevier By. All rights reserved.
dc.description82
dc.description1
dc.description333
dc.description339
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCNPq [476386/2007-1, 300593/2008-2]
dc.descriptionFundacao de Amparo a Pesquisa do Estado de Minas Gerais of Brazil [FAPEMIG-CEX-APQ 1906-502/07, CEX APQ 01837/08]
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationTalanta
dc.relationTalanta
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectCapillary zone electrophoresis
dc.subjectEthambutol
dc.subjectIsoniazid
dc.subjectRifampicin
dc.subjectPyrazinamide
dc.subjectPharmaceutical formulation
dc.subjectFixed-dose Combination
dc.subjectPharmaceutical Formulations
dc.subjectSpectrophotometric Determination
dc.subjectRifampicin
dc.subjectPyrazinamide
dc.subjectCalibration
dc.subjectValidation
dc.subjectEthambutol
dc.subjectLc
dc.subjectChromatography
dc.titleSimultaneous determination of first-line anti-tuberculosis drugs by capillary zone electrophoresis using direct UV detection
dc.typeArtículos de revistas


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