Use of a novel polyvinyl alcohol membrane as a pericardial substitute reduces adhesion formation and inflammatory response after cardiac reoperation

dc.creatorde Oliveira, PPM
dc.creatorBavaresco, VP
dc.creatorSilveira, LM
dc.creatorSchenka, AA
dc.creatorVilarinho, KAD
dc.creatorSeverino, ESBD
dc.creatorPetrucci, O
dc.date2014
dc.dateAPR
dc.date2014-07-30T19:16:31Z
dc.date2015-11-26T16:55:32Z
dc.date2014-07-30T19:16:31Z
dc.date2015-11-26T16:55:32Z
dc.date.accessioned2018-03-28T23:42:56Z
dc.date.available2018-03-28T23:42:56Z
dc.identifierJournal Of Thoracic And Cardiovascular Surgery. Mosby-elsevier, v. 147, n. 4, n. 1405, n. 1410, 2014.
dc.identifier0022-5223
dc.identifier1097-685X
dc.identifierWOS:000332772200060
dc.identifier10.1016/j.jtcvs.2013.07.021
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73246
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73246
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1277152
dc.descriptionBackground: Adhesions may increase the incidence of lethal complications of cardiac reoperations, which account for up to 20% of all open- heart surgeries. Herein, we describe the use of a polyvinyl alcohol membrane (PVAM) as a pericardial alternative and describe its performance during reoperation in a relevant animal model. Methods: The PVAM samples were reticulated by electron beam radiation and manipulated into a tube shape. After thoracotomy, the pericardium ofWistar rats was opened to expose the heart. Rats were treated by pushing the heart back into the thoracic cavity (Sham group), sprinkling the epicardium with talcum powder (Talc group), encircling the heart with PVAM(PVAMgroup), or sprinkling the epicardium with talcum powder before placing the PVAMto encircle the heart (PVAM+Talc group). Animals were recovered for 8 weeks and then euthanized. Macroscopic findings (ie, extent and severity of adhesions) were classified according to a 4-grade adhesion scale. The PVAM was tested for direct and indirect cytotoxicity with Vero cells. The water absorption capability and in vivo calcification after 8 weeks of subcutaneous implantation of the membrane were examined. Data were analyzed by analysis of variance and Bonferroni post hoc tests. Results: The PVAM group had lower adhesion scores than the Talc and Sham groups, as well as reduced epicardium thickness and inflammatory cell results, compared with the Talc and PVAM + Talc groups. The PVAM exhibited no direct or indirect cytotoxicity, good water absorption capability (42.4%+/- 0.9%), and negligible calcification after 8 weeks (4.42x10(-3) +/- 2.56x10(-3) percentage of the total mass). Conclusions: The PVAM shows promising properties for its potential use as a novel pericardial substitute.
dc.description147
dc.description4
dc.description1405
dc.description1410
dc.languageen
dc.publisherMosby-elsevier
dc.publisherNew York
dc.publisherEUA
dc.relationJournal Of Thoracic And Cardiovascular Surgery
dc.relationJ. Thorac. Cardiovasc. Surg.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectHypercholesterolemic Swine
dc.subjectCollagen Membrane
dc.subjectCoronary Surgery
dc.subjectClosure
dc.subjectAcid
dc.titleUse of a novel polyvinyl alcohol membrane as a pericardial substitute reduces adhesion formation and inflammatory response after cardiac reoperation
dc.typeArtículos de revistas


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