Collagen fiber reorganization in the rat ventral prostate following androgen deprivation: A possible role for smooth muscle cells

dc.creatorVilamaior, PSL
dc.creatorFelisbino, SL
dc.creatorTaboga, SR
dc.creatorCarvalho, HF
dc.date2000
dc.date37196
dc.date2014-12-02T16:29:30Z
dc.date2015-11-26T16:54:35Z
dc.date2014-12-02T16:29:30Z
dc.date2015-11-26T16:54:35Z
dc.date.accessioned2018-03-28T23:41:52Z
dc.date.available2018-03-28T23:41:52Z
dc.identifierProstate. Wiley-liss, v. 45, n. 3, n. 253, n. 258, 2000.
dc.identifier0270-4137
dc.identifierWOS:000165058100008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78937
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/78937
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78937
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276895
dc.descriptionBACKGROUND. Stroma plays an essential role in glandular function in different systems. In the prostate, it is responsible for the development and maintenance of the differentiated state of the epithelium. The marked reduction in the epithelial compartment of the prostate gland following castration is followed by a similarly important reorganization of the stroma. Ln this work, we characterized the reorganization of collagen fibers in the ventral prostate of castrated rats. METHODS. Histochemical tests and immunohistochemistry for type I and III collagens plus confocal microscopy of triple-labeled (collagen III, actin, and DNA) tissue sections were employed. RESULTS. We showed that collagen fibers are composed of type I and type III collagens and that they are progressively concentrated around the epithelial structures (ducts and acini) and become increasingly undulated and folded. Double-labeling of collagen fibers and F-actin demonstrated that smooth muscle cells (SMC) are intimately associated with collagen fibers. CONCLUSIONS. The results demonstrated a marked reorganization of the collagen fibers, and suggest an active role of the SMC in the reorganization of the fibrillar components of the stroma. Prostate 45:253-258, 2000. (C) 2000 Wiley-Liss, Inc.
dc.description45
dc.description3
dc.description253
dc.description258
dc.languageen
dc.publisherWiley-liss
dc.publisherNew York
dc.publisherEUA
dc.relationProstate
dc.relationProstate
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcastration
dc.subjecthistochemistry
dc.subjectpolarizing microscope
dc.subjectremodelling
dc.subjectstroma
dc.subjectPolarization Microscopy
dc.subjectPicrosirius
dc.subjectCastration
dc.titleCollagen fiber reorganization in the rat ventral prostate following androgen deprivation: A possible role for smooth muscle cells
dc.typeArtículos de revistas


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