Artículos de revistas
Highly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine (ES285) from a Morita-Baylis-Hillman adduct
Registro en:
Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 51, n. 19, n. 2597, n. 2599, 2010.
0040-4039
WOS:000277696000008
10.1016/j.tetlet.2010.02.169
Autor
Amarante, GW
Cavallaro, M
Coelho, F
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) We disclose herein a new approach for the highly diastereoselective total synthesis of the anti-tumoral agent (+/-)-Spisulosine. The synthesis was accomplished in seven steps with an overall yield of 10%. The key step involves the transformation of a Morita-Baylis-Hillman into an acyloin, which was subsequently used as substrate in a highly diastereoselective reductive amination reaction. (C) 2010 Elsevier Ltd. All rights reserved. 51 19 2597 2599 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)