EFFECT OF GLUCAGON ON INSULIN-RECEPTOR SUBSTRATE-1 (IRS-1) PHOSPHORYLATION AND ASSOCIATION WITH PHOSPHATIDYLINOSITOL 3-KINASE (PI-3-KINASE)

dc.creatorSAAD, MJA
dc.creatorHARTMANN, LGC
dc.creatorDECARVALHO, DS
dc.creatorGALORO, CAO
dc.creatorBRENELLI, SL
dc.creatorCARVALHO, CRO
dc.date1995
dc.dateAUG 14
dc.date2014-12-16T11:31:42Z
dc.date2015-11-26T16:54:13Z
dc.date2014-12-16T11:31:42Z
dc.date2015-11-26T16:54:13Z
dc.date.accessioned2018-03-28T23:41:29Z
dc.date.available2018-03-28T23:41:29Z
dc.identifierFebs Letters. Elsevier Science Bv, v. 370, n. 41671, n. 131, n. 134, 1995.
dc.identifier0014-5793
dc.identifierWOS:A1995RP89000029
dc.identifier10.1016/0014-5793(95)00809-N
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63919
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/63919
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63919
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276799
dc.descriptionIn the present study we have examined the levels and phosphorylation state of the insulin receptor and insulin receptor substrate 1 (IRS-1) as well as the association between IRS-I and phosphatidylinositol 3-kinase (PI 3-kinase) in the liver and muscle of rats treated with glucagon, There was a decrease in the insulin-stimulated receptor and IRS-1 phosphorylation levels which was paralleled by a reduced association between IRS-1 and PI 3-kinase in vivo in the liver and muscle of glucagon-treated rats, These observations suggest that glucagon, probably acting through cAMP, may impair insulin signaling in the three early steps in insulin action after binding.
dc.description370
dc.description41671
dc.description131
dc.description134
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationFebs Letters
dc.relationFEBS Lett.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectGLUCAGON
dc.subjectINSULIN RECEPTOR
dc.subjectINSULIN RECEPTOR SUBSTRATE
dc.subjectINSULIN ACTION
dc.subjectTYROSINE KINASE
dc.subjectRat Adipocytes
dc.subjectAnimal-models
dc.subjectProtein
dc.subjectLiver
dc.subjectKinase
dc.subjectMuscle
dc.subjectCells
dc.subjectCamp
dc.subjectPhosphatase
dc.subjectStimulation
dc.titleEFFECT OF GLUCAGON ON INSULIN-RECEPTOR SUBSTRATE-1 (IRS-1) PHOSPHORYLATION AND ASSOCIATION WITH PHOSPHATIDYLINOSITOL 3-KINASE (PI-3-KINASE)
dc.typeArtículos de revistas


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