Immunohistochemical study of stromal and vascular components of tonsillar polyps: high endothelial venules as participants of the polyp's lymphoid tissue

dc.creatorBarreto, I
dc.creatorCosta, AF
dc.creatorMartins, MT
dc.creatorFuruse, C
dc.creatorde Araujo, VC
dc.creatorAltemani, A
dc.date2011
dc.dateJUL
dc.date2014-07-30T18:05:56Z
dc.date2015-11-26T16:53:40Z
dc.date2014-07-30T18:05:56Z
dc.date2015-11-26T16:53:40Z
dc.date.accessioned2018-03-28T23:40:51Z
dc.date.available2018-03-28T23:40:51Z
dc.identifierVirchows Archiv. Springer, v. 459, n. 1, n. 65, n. 71, 2011.
dc.identifier0945-6317
dc.identifierWOS:000292306400008
dc.identifier10.1007/s00428-011-1088-8
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69961
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69961
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276637
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionTonsillar polyps are nonneoplastic lesions usually composed of variable amounts of lymphoid and vascular and connective tissues. All of them are generally assumed to be hamartomatous proliferations, but the profile of vascular and connective components has yet to be explored. The vascular system of the tonsils is complex and includes highly specialized structures (i.e., high endothelial venules (HEVs)) involved in lymphocyte homing into lymphoid tissues. In 14 tonsillar polyps and 26 control tonsils, an immunohistochemical study was performed using CD34 (blood vessels and HEVs), MECA-79 (HEVs), D2-40 (lymphatic vessels), Ki-67, collagens I and III, fibronectin, and tenascin-C. The polyps showed increased total lymphatic area, whereas the number of blood vessels and lymphatics and the blood vascular area did not differ significantly from those of control tonsils. Rare Ki-67+ endothelial cells were found. In the polyps, we detected, possibly for the first time, HEVs amid lymphoid tissue, and that the amount of the latter correlated positively with HEV density. The polyps also presented lesser amounts of fibronectin and collagens I and III than in normal tonsils, which were distributed in a disorganized fashion. Tenascin-C expression was uncommon in the polyps and control tonsils. Tonsillar polyps are composed of disorganized connective tissue and lymphatic channels which can be considered hamartomatous proliferations. However, the lymphoid component is possibly reactive due to its relationship with the HEVs. The highly differentiated phenotype of the HEVs and their complex biology are not in agreement with what would be expected for a component of hamartomatous nature.
dc.description459
dc.description1
dc.description65
dc.description71
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [04/13759-6, 10/51571-0]
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationVirchows Archiv
dc.relationVirchows Arch.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectTonsillar polyps
dc.subjectImmunohistochemistry
dc.subjectStromal component
dc.subjectHigh endothelial venules
dc.subjectPalatine Tonsil
dc.subjectExtracellular-matrix
dc.subjectRepair
dc.subjectTenascins
dc.subjectAdenoids
dc.titleImmunohistochemical study of stromal and vascular components of tonsillar polyps: high endothelial venules as participants of the polyp's lymphoid tissue
dc.typeArtículos de revistas


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