Impregnation of implantable polypropylene mesh with S-nitrosoglutathione-loaded poly(vinyl alcohol)

dc.creatorPrudente, A
dc.creatorRiccetto, CLZ
dc.creatorSimoes, MMDG
dc.creatorPires, BM
dc.creatorde Oliveira, MG
dc.date2013
dc.dateAUG 1
dc.date2014-07-30T18:06:25Z
dc.date2015-11-26T16:53:35Z
dc.date2014-07-30T18:06:25Z
dc.date2015-11-26T16:53:35Z
dc.date.accessioned2018-03-28T23:40:43Z
dc.date.available2018-03-28T23:40:43Z
dc.identifierColloids And Surfaces B-biointerfaces. Elsevier Science Bv, v. 108, n. 178, n. 184, 2013.
dc.identifier0927-7765
dc.identifierWOS:000319544000026
dc.identifier10.1016/j.colsurfb.2013.02.018
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70063
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70063
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276627
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionClinical complications of implantable polypropylene (PP) meshes used to repair urinary incontinence and vaginal prolapse may be associated with their low surface energy and consequent poor tissue integration. For improving tissue integration, we impregnated monofilament PP meshes with physically crosslinked poly(vinyl alcohol) (PVA), resulting in PVA deposits tightly attached inside the knot spaces of the PP knit. While preserving the mesh porosity, the PVA deposits acted as an array of hydrophilic regions leading to a great increase in the overall mesh wettability, reflected by a contact angle decrease from 111 to ca. 66 degrees. The PVA deposits were also used as reservoirs for the local release of S-nitrosoglutathione (GSNO), a nitric oxide (NO) donor. Plain and impregnated PP meshes (1.0 cm x 1.0 cm) were implanted in the subcutaneous tissue of 21 adult female Wistar rats. Histological analysis of the abdominal wall 21 days after the surgeries revealed lower edema and greater angiogenesis while a marked decrement of NOx concentration in the tissue surrounding the impregnated meshes was observed after 2 days. These results indicate that PVA and PVA/GSNO impregnation might be a new strategy for decreasing the frequency of mesh extrusion after PP mesh implants. (C) 2013 Elsevier B.V. All rights reserved.
dc.description108
dc.description178
dc.description184
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2008/09450-0]
dc.descriptionCNPq [309390/2011-7]
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationColloids And Surfaces B-biointerfaces
dc.relationColloid Surf. B-Biointerfaces
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectPolypropylene mesh
dc.subjectPoly(vinyl alcohol)
dc.subjectWettability
dc.subjectTissue integration
dc.subjectNitric oxide
dc.subjectNitric-oxide
dc.subjectPolyvinyl-alcohol
dc.subjectHydrogels
dc.subjectRats
dc.subjectChemiluminescence
dc.subjectReinforcement
dc.subjectMembranes
dc.subjectProlapse
dc.subjectWall
dc.titleImpregnation of implantable polypropylene mesh with S-nitrosoglutathione-loaded poly(vinyl alcohol)
dc.typeArtículos de revistas


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