Insights into the loss of muscle mass following B. jararacussu venom in mice

dc.creatorNeto, HS
dc.creatorVomero, VU
dc.creatorMarques, MJ
dc.date2004
dc.dateDEC 15
dc.date2014-11-18T09:05:52Z
dc.date2015-11-26T16:53:23Z
dc.date2014-11-18T09:05:52Z
dc.date2015-11-26T16:53:23Z
dc.date.accessioned2018-03-28T23:40:30Z
dc.date.available2018-03-28T23:40:30Z
dc.identifierToxicon. Pergamon-elsevier Science Ltd, v. 44, n. 8, n. 847, n. 850, 2004.
dc.identifier0041-0101
dc.identifierWOS:000225624700007
dc.identifier10.1016/j.toxicon.2004.08.007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80727
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/80727
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80727
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276567
dc.descriptionBothrops jararacussu snake venom produces myonecrosis and nerve degeneration. In this work, we investigated whether nerve lesions or impaired muscle regeneration contributed to the permanent loss of muscle mass, a long-term sequela of envenoming. The right soleus muscle of adult male mice was injected with B. jararacussu venom (80 mug) while the left muscle received only saline (control). The mice were killed after 2 and 3 months and the muscles were removed and processed for examination by transmission electron microscopy and light microscopy. The nerve fibers, Schwann cells and neuromuscular junctions had regenerated in venom-treated muscle. The total number of muscle fibers was significantly lower (p < 0.05) than in the control (617 +/- 48 versus 1235 +/- 97, respectively; mean +/- SEM, n = 10). These results show that the loss of muscle mass was most likely related to a decrease in the ability of the muscle to regenerate rather than to nerve lesions. (C) 2004 Elsevier Ltd. All rights reserved.
dc.description44
dc.description8
dc.description847
dc.description850
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationToxicon
dc.relationToxicon
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectBothrops jararacussu
dc.subjectmuscular atrophy
dc.subjectmuscle regeneration
dc.subjectsnake venom
dc.subjectHematopoietic Stem-cells
dc.subjectLocal Tissue-damage
dc.subjectBothrops-jararacussu
dc.subjectSkeletal-muscle
dc.subjectSnake-venom
dc.subjectPhospholipases A(2)
dc.subjectRegeneration
dc.subjectEpidemiology
dc.subjectDegeneration
dc.subjectBrazil
dc.titleInsights into the loss of muscle mass following B. jararacussu venom in mice
dc.typeArtículos de revistas


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