Immunophenotypic characterization and distribution of dendritic cells in odontogenic cystic lesions

dc.creatorMatos, FTC
dc.creatorRizo, VHT
dc.creatorAlmeida, LY
dc.creatorTirapelli, C
dc.creatorSilva-Sousa, YTC
dc.creatorAlmeida, OP
dc.creatorLeon, JE
dc.date2013
dc.dateJAN
dc.date2014-07-30T18:05:58Z
dc.date2015-11-26T16:53:21Z
dc.date2014-07-30T18:05:58Z
dc.date2015-11-26T16:53:21Z
dc.date.accessioned2018-03-28T23:40:28Z
dc.date.available2018-03-28T23:40:28Z
dc.identifierOral Diseases. Wiley-blackwell, v. 19, n. 1, n. 85, n. 91, 2013.
dc.identifier1354-523X
dc.identifierWOS:000312247100009
dc.identifier10.1111/j.1601-0825.2012.01960.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69978
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69978
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276559
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionOBJECTIVE: To analyze the expression and distribution patterns of mature dendritic cells (mDCs) and immature DCs (imDCs) in radicular cysts (RCs), dentigerous cysts (DtCs), and keratocystic odontogenic tumors (KCOTs). Materials and methods: Forty-nine odontogenic cystic lesions (OCLs) (RCs, n = 20; DtCs, n = 15; KCOTs, n = 14) were assessed using the following markers: S100, CD1a and CD207 for imDCs; and CD83 for mDCs. Results: Almost all cases were S100, CD1a, and CD207 positive, whereas 63% were CD83 positive. RCs presented greater number of immunostained cells, followed by DtCs, and KCOTs. The number of S100+ cells was greater than both CD1a+ and CD207+ cells (P < 0.001), which showed approximately similar amounts, followed by lower number of CD83+ cells (P < 0.001) in each OCL type. Different from S100+ cells, both CD1a+ and CD207+ cells on the epithelium (P < 0.05) and CD83+ cells on the capsule (P < 0.05) were preferentially observed. In RCs, significant correlation was found between the thickness epithelium with S100+ and CD1a+ cells, and between the degree of inflammation with CD83+ cells. Conclusions: Dendritic cell populations in OCLs can be phenotypically heterogeneous, and it could represent distinct lineages and/or functional stages. It is suggested that besides DC-mediated immune cell interactions, DC-mediated tissue differentiation and maintenance in OCLs should also be considered. Oral Diseases (2012) 19, 8591
dc.description19
dc.description1
dc.description85
dc.description91
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationOral Diseases
dc.relationOral Dis.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectodontogenic cysts
dc.subjectjaws
dc.subjectoral
dc.subjectdendritic cells
dc.subjectimmunohistochemistry
dc.subjectAntigen-presenting Cells
dc.subjectLangerhans Cells
dc.subjectIn-situ
dc.subjectApical Periodontitis
dc.subjectOral-mucosa
dc.subjectExpression
dc.subjectMature
dc.subjectMacrophages
dc.subjectKeratocyst
dc.subjectGranulomas
dc.titleImmunophenotypic characterization and distribution of dendritic cells in odontogenic cystic lesions
dc.typeArtículos de revistas


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