REVERSAL OF LEARNED HELPLESSNESS BY CHRONIC LITHIUM TREATMENT AT A PROPHYLACTIC LEVEL

dc.creatorFARIA, MS
dc.creatorTEIXEIRA, NA
dc.date1993
dc.dateNOV
dc.date2014-07-30T18:27:12Z
dc.date2015-11-26T16:53:21Z
dc.date2014-07-30T18:27:12Z
dc.date2015-11-26T16:53:21Z
dc.date.accessioned2018-03-28T23:40:25Z
dc.date.available2018-03-28T23:40:25Z
dc.identifierBrazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 26, n. 11, n. 1201, n. 1212, 1993.
dc.identifier0100-879X
dc.identifierWOS:A1993MG75900008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71110
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71110
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276552
dc.description1. The effect of chronic lithium (Li) administration in a learned helplessness (LH) model was investigated. Female Wistar rats (190-210 g) received either tap water ad libitum (N = 56) or 20 mM LiCl (N = 63) in the drinking water or were water restricted (35% based on tower liquid intake of rats receiving lithium, N = 40) for 30 days. On the 28th day, each of these groups was divided into three subgroups which received escapable (ES), inescapable (IS) or no shock (NS) treatment in shuttle boxes. All groups were submitted to the escape test on the 29th day and sacrificed on the 30th day, when blood samples were taken for measurement of serum lithium, sodium and potassium concentrations. 2. The NS group had lower serum Li levels (0.36 +/- 0.06, N = 15) than the ES (0.46 +/- 0.07, N = 15) or IS group (0.44 +/- 0.09, N = 25). The Li-pretreated group subjected to IS had a more effective escape performance than the IS group under water restriction and showed the same behavior as animals not submitted to shocks. 3. We conclude that chronic treatment with Li at a serum level of 0.44 +/- 0.09 mEq/l prevents learned helplessness in rats. These results corroborate the validity of the use of this model for the assessment of the capacity of Li to protect against some depressive episodes.
dc.description26
dc.description11
dc.description1201
dc.description1212
dc.languageen
dc.publisherAssoc Bras Divulg Cientifica
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationBrazilian Journal Of Medical And Biological Research
dc.relationBrazilian J. Med. Biol. Res.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectLITHIUM
dc.subjectPROPHYLACTIC LEVELS
dc.subjectLEARNED HELPLESSNESS
dc.subjectBIPOLAR DISORDERS
dc.subjectAnimal-models
dc.subjectRats
dc.subjectDepression
dc.subjectParadigm
dc.subjectAntidepressants
dc.subjectBehavior
dc.subjectSodium
dc.titleREVERSAL OF LEARNED HELPLESSNESS BY CHRONIC LITHIUM TREATMENT AT A PROPHYLACTIC LEVEL
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución