Artículos de revistas
Histopathological changes in avian kidney caused by Bothrops insularis (jararaca ilhoa) venom and a phospholipase A(2)-containing fraction
Registro en:
Histology And Histopathology. F Hernandez, v. 16, n. 1, n. 185, n. 195, 2001.
0213-3911
WOS:000166311900022
Autor
Hofling, MAD
Paronetto, CCL
Cogo, JC
Rodrigues-Simioni, L
D'Abreu, ACF
Institución
Resumen
The histopathological changes induced in avian kidney by the intramuscular injection of Bothrops insularis (jararaca ilhoa) venom and its phospholipase A(2) (PLA(2))-containing fraction were examined. Acute experiments (3 h and 24 h) with B. insularis crude venom (20 mug and 80 mug) or its PLA(2)-contaning fraction (10 mug and 40 mug) resulted in significant structural damage to the kidneys of 5-12-day-old chicks. Histopathological analysis indicated that the venom and its fraction acted on the renal tubules and glomeruli. The morphological changes, although widespread, varied in intensity from cell to cell, and from tubule to tubule in venom-injected chicks. The tubular and glomerular changes produced by the venom and its PLA(2)-containing fraction may be the result of a direct cytotoxic effect potentiated by ischemia-related disturbances in the regional hemodynamics. The venom and its fraction affected more segments along reptilian-type nephrons than along mammalian ones. This divergent sensitivity to the venom and its fraction may reflect the species-specific characteristics of B. insularis snake, an example of geographical isolation influencing its diet which is almost exclusively avian. 16 1 185 195