OPIOID NATURE OF LEARNED HELPLESSNESS AND STRESS-INDUCED ANALGESIA OBSERVED WITHOUT REEXPOSURE TO SHOCK

dc.creatorHUNZIKER, MHL
dc.date1992
dc.dateAPR
dc.date2014-07-30T18:02:49Z
dc.date2015-11-26T16:52:35Z
dc.date2014-07-30T18:02:49Z
dc.date2015-11-26T16:52:35Z
dc.date.accessioned2018-03-28T23:39:32Z
dc.date.available2018-03-28T23:39:32Z
dc.identifierBehavioural Pharmacology. Rapid Science Publishers, v. 3, n. 2, n. 117, n. 121, 1992.
dc.identifier0955-8810
dc.identifierWOS:A1992HW24900003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69497
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69497
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276320
dc.descriptionIt has been shown that uncontrollable shocks that produce learned helplessness also produce long-term opioid analgesia if the animal is re-exposed to shock immediately before the test. The present study was conducted in order to investigate if this effect can be observed 24 h after the uncontrollable shock treatment without re-exposure to shock, and if it is opioid mediated. Long-term analgesia was found in the absence of re-exposure to shock, and was prevented by an i.p. injection of naloxone (10 mg/kg) administered 10 min before the test. The learned helplessness effect produced by the same shock treatment was prevented by the administration of 10 and 20 mg/kg of naloxone 10 min before the shuttle-box test, but not by a lower naloxone dose (5 mg/kg). These findings suggest that the shock re-exposure requirement proposed in previous studies is not crucial in determining the long-term analgesia, and that both the long-term analgesia and the learned helplessness effect produced by this shock treatment were opioid mediated.
dc.description3
dc.description2
dc.description117
dc.description121
dc.languageen
dc.publisherRapid Science Publishers
dc.publisherLondon
dc.publisherInglaterra
dc.relationBehavioural Pharmacology
dc.relationBehav. Pharmacol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectLEARNED HELPLESSNESS
dc.subjectSTRESS-INDUCED ANALGESIA
dc.subjectOPIOID ANALGESIA
dc.subjectUNCONTROLLABLE SHOCKS
dc.subjectNALOXONE
dc.subjectRAT
dc.subjectInescapable Shock
dc.subjectCross-tolerance
dc.subjectNature Depends
dc.subjectRat
dc.subjectMorphine
dc.subjectStrain
dc.titleOPIOID NATURE OF LEARNED HELPLESSNESS AND STRESS-INDUCED ANALGESIA OBSERVED WITHOUT REEXPOSURE TO SHOCK
dc.typeArtículos de revistas


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