Inhibition of tonic spinal glutamatergic activity induces antinociception in the rat

dc.creatorTambeli, CH
dc.creatorParada, CA
dc.creatorLevine, JD
dc.creatorGear, RW
dc.date2002
dc.dateOCT
dc.date2014-11-18T07:14:01Z
dc.date2015-11-26T16:52:22Z
dc.date2014-11-18T07:14:01Z
dc.date2015-11-26T16:52:22Z
dc.date.accessioned2018-03-28T23:39:18Z
dc.date.available2018-03-28T23:39:18Z
dc.identifierEuropean Journal Of Neuroscience. Blackwell Publishing Ltd, v. 16, n. 8, n. 1547, n. 1553, 2002.
dc.identifier0953-816X
dc.identifierWOS:000178922900017
dc.identifier10.1046/j.1460-9568.2002.02204.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80651
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/80651
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80651
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276261
dc.descriptionInhibition of tonic activity in spino-supraspinal projection neurons induces heterosegmental antinociception that is mediated by opioid receptors in nucleus accumbens. To investigate the origin of this tonic activity, we evaluated the ability of inhibiting neurotransmission in the spinal cord to produce heterosegmental antinociception in the trigeminal nociceptive jaw-opening reflex (JOR) in the rat. Spinal intrathecal administration of calcium channel blockers attenuated the JOR, suggesting that the tonic spinal activity depends on synaptic input. To identify the excitatory neurotransmitter receptors involved, selective antagonists for AMPA/kainate, mGluR(1), NMDA or NK1 receptors were administered intrathecally to the spinal cord. The AMPA/kainate and mGluR(1) receptor antagonists, but not the NMDA or NK1 receptor antagonists, induced antinociception, which was antagonized by intra-accumbens administration of the selective mu-opioid receptor antagonist CTOP. Thus, inhibition of tonic spinal glutamatergic activity resulted in supraspinally mediated antinociception. As this antinociception occurred in the absence of interventions that would produce a facilitated nociceptive state, this tonic glutamatergic activity is important in setting nociceptive threshold.
dc.description16
dc.description8
dc.description1547
dc.description1553
dc.languageen
dc.publisherBlackwell Publishing Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationEuropean Journal Of Neuroscience
dc.relationEur. J. Neurosci.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectantinociception
dc.subjectAMPA
dc.subjectkainate
dc.subjectNK1
dc.subjectmGluR1
dc.subjectNMDA
dc.subjectexcitatory
dc.subjectnucleus accumbens
dc.subjectglutamate
dc.subjectJaw-opening Reflex
dc.subjectEnkephalin-like Material
dc.subjectVentrolateral Orbital Cortex
dc.subjectPeriaqueductal Gray-matter
dc.subjectAnterior Pretectal Nucleus
dc.subjectDorsal Horn Neurons
dc.subjectReceptor Antagonists
dc.subjectCa2+ Channels
dc.subjectN-type
dc.subjectP-type
dc.titleInhibition of tonic spinal glutamatergic activity induces antinociception in the rat
dc.typeArtículos de revistas


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