Electrocatalytic activity of 4-nitrophthalonitrile-modified electrode for the L-glutathione detection

dc.creatorLima, PR
dc.creatorSantos, WJR
dc.creatorOliveira, AB
dc.creatorGoulart, MO
dc.creatorKubota, LT
dc.date2008
dc.dateAUG 5
dc.date2014-07-30T17:24:45Z
dc.date2015-11-26T16:52:17Z
dc.date2014-07-30T17:24:45Z
dc.date2015-11-26T16:52:17Z
dc.date.accessioned2018-03-28T23:39:13Z
dc.date.available2018-03-28T23:39:13Z
dc.identifierJournal Of Pharmaceutical And Biomedical Analysis. Pergamon-elsevier Science Ltd, v. 47, n. 41763, n. 758, n. 764, 2008.
dc.identifier0731-7085
dc.identifierWOS:000257220300015
dc.identifier10.1016/j.jpba.2008.03.006
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65475
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65475
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276240
dc.descriptionThe present work describes the substantial electrocatalytic activity of (NC)(2)C6H3-NHOH/(NC)(2)C6H3-NO redox couple-modified electrode toward the low voltage detection Of L-glutathione (GSH), in neutral medium, at an applied potential of 0.4V versus Ag/AgCl. After optimizing the operational conditions, the sensor provided a linear response range for GSH from 8.0 up to 83.0 mu mol L-1 with sensitivity, detection and quantification limits of 54 nA L mu mol(-1), 2.7 mu mol L-1 and 8.0 mu mol L-1, respectively. The proposed sensor presented higher sensitivity when compared to other modified electrodes described in the literature and showed a stable response for at least 100 successive determinations. The repeatability of the measurements with the same sensor and different sensors, evaluated in terms of relative standard deviation, were 4.1 and 5.0%, respectively, for n = 10. The developed sensor was applied for GSH determination in yeast extract and the results were statistically the same with those obtained by the comparative method described in the literature at a confidence level of 95%. (C) 2008 Elsevier B.V. All rights reserved.
dc.description47
dc.description41763
dc.description758
dc.description764
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationJournal Of Pharmaceutical And Biomedical Analysis
dc.relationJ. Pharm. Biomed. Anal.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subject4-nitrophthalonitrile
dc.subjectglutathione
dc.subjectamperometric sensor
dc.subjectyeast extract
dc.subjectPerformance Liquid-chromatography
dc.subjectReduced Glutathione
dc.subjectAmperometric Detection
dc.subjectL-cysteine
dc.subjectSpectrophotometric Determination
dc.subjectCatalytic-oxidation
dc.subjectCarbon Nanotubes
dc.subjectThiols
dc.subjectBiosensor
dc.titleElectrocatalytic activity of 4-nitrophthalonitrile-modified electrode for the L-glutathione detection
dc.typeArtículos de revistas


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