In vitro antiviral activity of Brazilian plants (Maytenus ilicifolia and Aniba rosaeodora) against bovine herpesvirus type 5 and avian metapneumovirus

dc.creatorKohn, LK
dc.creatorQueiroga, CL
dc.creatorMartini, MC
dc.creatorBarata, LE
dc.creatorPorto, PSS
dc.creatorSouza, L
dc.creatorArns, CW
dc.date2012
dc.dateOCT
dc.date2014-07-30T18:02:01Z
dc.date2015-11-26T16:52:12Z
dc.date2014-07-30T18:02:01Z
dc.date2015-11-26T16:52:12Z
dc.date.accessioned2018-03-28T23:39:07Z
dc.date.available2018-03-28T23:39:07Z
dc.identifierPharmaceutical Biology. Informa Healthcare, v. 50, n. 10, n. 1269, n. 1275, 2012.
dc.identifier1388-0209
dc.identifierWOS:000308526600010
dc.identifier10.3109/13880209.2012.673627
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69350
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69350
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276213
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionContext: Medicinal plants are well known for their use in traditional folk medicine as treatments for many diseases including infectious diseases. Objective: Six Brazilian medicinal plant species were subjected to an antiviral screening bioassay to investigate and evaluate their biological activities against five viruses: bovine herpesvirus type 5 (BHV-5), avian metapneumovirus (aMPV), murine hepatitis virus type 3, porcine parvovirus and bovine respiratory syncytial virus. Materials and methods: The antiviral activity was determined by a titration technique that depends on the ability of plant extract dilutions (25 or 2.5 mu g/mL) to inhibit the viral induced cytopathic effect and the extracts' inhibition percentage (IP). Results: Two medicinal plant species showed potential antiviral activity. The Aniba rosaeodora Ducke (Lauraceae) extract had the best results, with 90% inhibition of viral growth at 2.5 mu g/mL when the extract was added during the replication period of the aMPV infection cycle. The Maytenus ilicifolia (Schrad.) Planch. (Celastraceae) extracts at a concentration of 2.5 mu g/mL exhibited antiviral activity during the attachment phase of BHV-5 (IP = 100%). Discussion and conclusion: The biomonitored fractionation of the active extracts from M. ilicifolia and A. rosaeodora could be a potential tool for identifying their active compounds and determining the exact mechanism of action.
dc.description50
dc.description10
dc.description1269
dc.description1275
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherInforma Healthcare
dc.publisherLondon
dc.publisherInglaterra
dc.relationPharmaceutical Biology
dc.relationPharm. Biol.
dc.rightsfechado
dc.rightshttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.sourceWeb of Science
dc.subjectAntiviral
dc.subjectcrude extract
dc.subjectplants
dc.subjectsulforhodamine B
dc.subjectMTT
dc.subjectRespiratory Syncytial Virus
dc.subjectTumor-cell Lines
dc.subjectMedicinal-plants
dc.subjectNatural-products
dc.subjectAgents
dc.subjectAssay
dc.subjectLinalool
dc.subjectExtracts
dc.subjectGrowth
dc.titleIn vitro antiviral activity of Brazilian plants (Maytenus ilicifolia and Aniba rosaeodora) against bovine herpesvirus type 5 and avian metapneumovirus
dc.typeArtículos de revistas


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