Expression of minichromosome maintenance 2, Ki-67, and geminin in oral nevi and melanoma

dc.creatorde Andrade, BAB
dc.creatorLeon, JE
dc.creatorCarlos, R
dc.creatorDelgado-Azanero, W
dc.creatorMosqueda-Taylor, A
dc.creatorde Almeida, OP
dc.date2013
dc.dateFEB
dc.date2014-07-30T17:32:22Z
dc.date2015-11-26T16:51:52Z
dc.date2014-07-30T17:32:22Z
dc.date2015-11-26T16:51:52Z
dc.date.accessioned2018-03-28T23:38:40Z
dc.date.available2018-03-28T23:38:40Z
dc.identifierAnnals Of Diagnostic Pathology. Elsevier Science Inc, v. 17, n. 1, n. 32, n. 36, 2013.
dc.identifier1092-9134
dc.identifierWOS:000312427700007
dc.identifier10.1016/j.anndiagpath.2012.05.001
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66485
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66485
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276103
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionEvaluation of cell cycle using antibodies against nuclear proteins involved in regulating DNA replication has gained special interest in the effort to predict biologic behavior of benign and malignant tumors. The aim of this study was to analyze the expression of minichromosome maintenance 2, Ki-67, and geminin in oral nevi and melanomas. Expression of these cell proliferation markers was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index of each proliferation marker was assessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide. Minichromosome maintenance 2, Ki-67, and geminin were rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of these cell proliferation markers, particularly minichromosome maintenance 2, indicating it is a more sensitive marker in primary oral melanomas than Ki-67 and geminin. These results indicate that these markers may be involved in the pathogenesis of oral melanomas and could be eventually useful as an additional diagnostic tool for differential diagnosis of oral benign and malignant melanocytic lesions. (C) 2013 Elsevier Inc. All rights reserved.
dc.description17
dc.description1
dc.description32
dc.description36
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCAPES [CAPES 8661-11-1]
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationAnnals Of Diagnostic Pathology
dc.relationAnn. Diagn. Pathol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectOral melanoma
dc.subjectOral nevi
dc.subjectMcm-2
dc.subjectKi-67
dc.subjectGeminin
dc.subjectImmunohistochemistry
dc.subjectSquamous-cell Carcinomas
dc.subjectPrognostic Markers
dc.subjectProtein Expression
dc.subjectTumors
dc.subjectCancer
dc.subjectMcm-2
dc.subjectProliferation
dc.subjectDysplasia
dc.subjectKinetics
dc.subjectBenign
dc.titleExpression of minichromosome maintenance 2, Ki-67, and geminin in oral nevi and melanoma
dc.typeArtículos de revistas


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