Artículos de revistas
Chernoenzymatic syntheses of (R)-2-bromo-, (R)-2-chloro- and (R)-2-azido-1-(1,3-benzodioxol-5-yl)-1-ethanol
Registro en:
Tetrahedron-asymmetry. Pergamon-elsevier Science Ltd, v. 15, n. 17, n. 2615, n. 2620, 2004.
0957-4166
WOS:000224017700006
10.1016/j.tetasy.2004.07.029
Autor
Antunes, H
Fardelone, LC
Rodrigues, JAR
Moran, PJS
Institución
Resumen
Enantioselective reductions of 2-X-1-(1,3-benzodioxol-5-yl)-1-ethanones, (X = Cl, Br, N-3) by Rhodothorula glutinis CCT 2182 afforded the corresponding (R)-ethanols in good to excellent yields (57-99%) and excellent enantiomeric excesses (>99%). These alcohols may be used as raw materials for the preparation of the pharmaceuticals (R)-(-)-epinephrine, (R)-(-)-norepinephrine and (R)-(-)-isoproterenol. (C) 2004 Elsevier Ltd. All rights reserved. 15 17 2615 2620