In situ assessment of atorvastatin impurity using MALDI mass spectrometry imaging (MALDI-MSI)

dc.creatorRodrigues, LR
dc.creatorde Oliveira, DN
dc.creatorFerreira, MS
dc.creatorCatharino, RR
dc.date2014
dc.date45717
dc.date2014-07-30T18:01:56Z
dc.date2015-11-26T16:51:32Z
dc.date2014-07-30T18:01:56Z
dc.date2015-11-26T16:51:32Z
dc.date.accessioned2018-03-28T23:38:19Z
dc.date.available2018-03-28T23:38:19Z
dc.identifierAnalytica Chimica Acta. Elsevier Science Bv, v. 818, n. 32, n. 38, 2014.
dc.identifier0003-2670
dc.identifier1873-4324
dc.identifierWOS:000332961900005
dc.identifier10.1016/j.aca.2014.01.050
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69311
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69311
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276011
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe analysis of impurities and degradation products in pharmaceutical preparations are usually performed by chromatographic techniques such as high-performance liquid chromatography (HPLC). This approach demands extensive analysis time, mostly due to extraction and separation phases. These steps must be carried out in samples in order to adapt them to the requirements of the analytical method of choice. In the present contribution, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was employed to quantify an important degradation product in atorvastatin calcium 80 mg tablets: the atorvastatin lactone. Through the standard of the impurity, it was possible to perform quantitative analysis directly on the drug tablet, using a quick and novel approach, suitable for quality control processes in the pharmaceutical industry. (C) 2014 Elsevier B.V. All rights reserved.
dc.description818
dc.description32
dc.description38
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionINCT
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationAnalytica Chimica Acta
dc.relationAnal. Chim. Acta
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAtorvastatin
dc.subjectImpurities
dc.subjectQuality control
dc.subjectMass spectrometry imaging
dc.subjectDegradation-products
dc.subjectStress Degradation
dc.subjectTof-ms
dc.subjectLocalization
dc.subjectQuantitation
dc.subjectStatin
dc.subjectDrugs
dc.subjectLc
dc.titleIn situ assessment of atorvastatin impurity using MALDI mass spectrometry imaging (MALDI-MSI)
dc.typeArtículos de revistas


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