Functional VEGF haplotypes affect the susceptibility to hypertension

dc.creatorSandrim, VC
dc.creatorLuizon, MR
dc.creatorIzidoro-Toledo, TC
dc.creatorCoelho, EB
dc.creatorMoreno, H
dc.creatorTanus-Santos, JE
dc.date2013
dc.dateJAN
dc.date2014-07-30T17:47:14Z
dc.date2015-11-26T16:51:29Z
dc.date2014-07-30T17:47:14Z
dc.date2015-11-26T16:51:29Z
dc.date.accessioned2018-03-28T23:38:15Z
dc.date.available2018-03-28T23:38:15Z
dc.identifierJournal Of Human Hypertension. Nature Publishing Group, v. 27, n. 1, n. 31, n. 37, 2013.
dc.identifier0950-9240
dc.identifierWOS:000311994000006
dc.identifier10.1038/jhh.2011.110
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/67686
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/67686
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275990
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionWe examined whether vascular endothelial growth factor (VEGF) polymorphisms (C-2578A, G-1154A and G-634C) are associated with hypertension, response to antihypertensive therapy and nitric oxide (NO) formation. Substudy 1 compared the distribution of VEGF genotypes and haplotypes in 178 patients with arterial hypertension (100 whites and 78 blacks) and 186 healthy controls (115 whites and 71 blacks). Substudy 2 compared the distribution of VEGF markers in 82 patients with controlled hypertension, 89 patients with resistant hypertension and 101 normotensive (NT) patients. In substudy 3, plasma nitrite/nitrate (NOx) levels were determined (chemiluminescence assay) in 64 NT subjects and 48 hypertensive (HTN) subjects, and the distribution of VEGF markers was compared in subjects having low NOx with subjects having high NOx. Although the substudy 1 showed no differences in genotypes or allele distributions for the three VEGF polymorphisms between NT and HTN subjects, the 'C-A-G' haplotype was more common in white NT subjects than in the white HTN subjects, and the 'C-A-C' haplotype was more frequent in black and white HTN subjects than in black and white NT subjects. The substudy 2 showed similar results, with no differences between responsive and resistant HTN subjects. The substudy 3 showed that the 'C-A-G' haplotype, which had a protective effect against hypertension, was significantly more common in subjects with higher NOx concentrations than in subjects with lower NOx concentrations. VEGF haplotypes are associated with hypertension, and the haplotype associated with normotension was more common in subjects with increased NO formation, possibly offering a mechanistic clue for our findings. Journal of Human Hypertension (2013) 27, 31-37; doi:10.1038/jhh.2011.110; published online 22 December 2011
dc.description27
dc.description1
dc.description31
dc.description37
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherNature Publishing Group
dc.publisherLondon
dc.publisherInglaterra
dc.relationJournal Of Human Hypertension
dc.relationJ. Hum. Hypertens.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectVEGF
dc.subjectnitric oxide
dc.subjectNOx
dc.subjecthaplotypes
dc.subjectpolymorphisms
dc.subjectEndothelial Growth-factor
dc.subjectNitric-oxide Synthase
dc.subjectDependent Relaxation
dc.subjectMetastatic Melanoma
dc.subjectEnos Haplotypes
dc.subjectGene Promoter
dc.subjectPolymorphisms
dc.subjectCancer
dc.subjectTranslation
dc.subjectAssociation
dc.titleFunctional VEGF haplotypes affect the susceptibility to hypertension
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución