dc.creatorde Almeida, MD
dc.creatorde Aro, AA
dc.creatorGuerra, FD
dc.creatorVieira, CP
dc.creatorVidal, BD
dc.creatorPimentel, ER
dc.date2012
dc.date2014-07-30T17:24:44Z
dc.date2015-11-26T16:51:27Z
dc.date2014-07-30T17:24:44Z
dc.date2015-11-26T16:51:27Z
dc.date.accessioned2018-03-28T23:38:14Z
dc.date.available2018-03-28T23:38:14Z
dc.identifierConnective Tissue Research. Informa Healthcare, v. 53, n. 6, n. 542, n. 547, 2012.
dc.identifier0300-8207
dc.identifier1607-8438
dc.identifierWOS:000310986200016
dc.identifier10.3109/03008207.2012.710671
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65470
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65470
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275985
dc.descriptionThe aim of this study was to investigate the effect of electroacupuncture (EA) on the composition and organization of the extracellular matrix of the rat Achilles tendon after a partial transection during the proliferative phase of healing. Wistar rats were divided into three groups: rats that were not tenotomized (G1), tenotomized rats (G2), and rats that were tenotomized and submitted to EA (G3). EA was applied 15 days after injury at the ST36 and BL57 acupoints for 20 min, three times per week on alternate days for a total of six sessions. Biochemical analyses were performed using non-collagenous proteins, glycosaminoglycans, and hydroxyproline quantifications. An analysis of metalloproteinase-2 was carried out by zymography. The general organization of the extracellular matrix and the metachromasy of the tendons were analyzed under light microscopy. The organization of the bundles of collagen fibers was analyzed by birefringence analysis. The results showed that EA did not alter the concentration of non-collagenous proteins or glycosaminoglycans or the enzymatic activity of metalloproteinase-2 in the transected tendons. However, the concentration of hydroxyproline was significantly increased when these tendons were treated by EA. The analysis of birefringence showed a higher organization of collagen fibers in the group treated by EA. These results indicate, for the first time, that EA may offer therapeutic benefits for the treatment of tendon injuries by increasing the concentration of collagen and by inducing a better molecular organization of the collagen fibers, which may improve the mechanical strength of the tendon after injury.
dc.description53
dc.description6
dc.description542
dc.description547
dc.languageen
dc.publisherInforma Healthcare
dc.publisherLondon
dc.publisherInglaterra
dc.relationConnective Tissue Research
dc.relationConnect. Tissue Res.
dc.rightsfechado
dc.rightshttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.sourceWeb of Science
dc.subjectacupuncture
dc.subjectextracellular matrix
dc.subjectmechanotransduction
dc.subjectfibroblasts
dc.subjectrepair
dc.subjectLow-frequency Electroacupuncture
dc.subjectSympathetic Postganglionic Neurons
dc.subjectAchilles-tendon
dc.subjectExtracellular-matrix
dc.subjectConnective-tissue
dc.subjectAcupuncture
dc.subjectInflammation
dc.subjectProteoglycans
dc.subjectExpression
dc.subjectRepair
dc.titleElectroacupuncture Increases the Concentration and Organization of Collagen in a Tendon Healing Model in Rats
dc.typeArtículos de revistas


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