Expression of New Red Cell-Related Genes in Erythroid Differentiation

dc.creatorDe Andrade, T
dc.creatorMoreira, L
dc.creatorDuarte, A
dc.creatorLanaro, C
dc.creatorDe Albuquerque, D
dc.creatorSaad, S
dc.creatorCosta, F
dc.date2010
dc.dateFEB
dc.date2014-11-18T03:50:05Z
dc.date2015-11-26T16:50:50Z
dc.date2014-11-18T03:50:05Z
dc.date2015-11-26T16:50:50Z
dc.date.accessioned2018-03-28T23:37:38Z
dc.date.available2018-03-28T23:37:38Z
dc.identifierBiochemical Genetics. Springer/plenum Publishers, v. 48, n. 41671, n. 164, n. 171, 2010.
dc.identifier0006-2928
dc.identifierWOS:000273846300016
dc.identifier10.1007/s10528-009-9310-y
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66487
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/66487
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66487
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275834
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUsing a suppression subtractive hybridization method, we have previously identified genes differentially expressed in erythroid cells heterozygous for large deletions in beta-like globin cluster. Herein, we investigated the expression of four newly detected red cell-related genes in erythroid differentiation. ARID1B and TSPYL1, genes with chromatin remodeling properties, presented similar patterns of expression with an upregulation after erythropoietin (EPO) addition, similar to previous data found in reticulocytes. ZHX2, a transcriptional repressor, was downregulated, and a redoxin-related gene, SH3BGRL2, had higher levels of expression on differentiation. These are the first investigations of these newly described genes in erythroid differentiation and demonstrate that the expression of these genes is affected by EPO stimulation. These genes may participate in globin regulation and may be important in the normal physiology of erythrocytes.
dc.description48
dc.description41671
dc.description164
dc.description171
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionHemocenter
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [02/03396-8]
dc.languageen
dc.publisherSpringer/plenum Publishers
dc.publisherNew York
dc.publisherEUA
dc.relationBiochemical Genetics
dc.relationBiochem. Genet.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectGlobin
dc.subjectTranscription
dc.subjectErythroid differentiation
dc.subjectChromatin remodeling
dc.subjectOxidative stress
dc.subjectChromatin-remodeling Complex
dc.subjectQuantitative Trait Locus
dc.subjectFetal-hemoglobin
dc.subjectHereditary Persistence
dc.subjectLiquid Culture
dc.subjectFamily
dc.subjectIdentification
dc.subjectProteins
dc.subjectBinding
dc.titleExpression of New Red Cell-Related Genes in Erythroid Differentiation
dc.typeArtículos de revistas


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